methotrexate is an anti-rheumatic agent used as a first-line tretment for rheumatoid arthritis. hematological malignancies like lymphoma or acute myeloid leukemia have been reported to be secondary to treatment with methotrexate, but are very uncommon. we report here the first moroccan case of ra patient on low dose mtx, who developed aml. we also reviewed all similar cases.

To characterize the biology and optimal therapy of acute mixed-lineage leukemia in children, we reviewed the pathologic and clinical features, including response to therapy, of 35 patients with mixed-lineage leukemia. The majority of cases (91%) had blasts cells that simultaneously expressed either T-lineage plus myeloid markers (T/myeloid, n = 20) or B-lineage plus myeloid markers (B/myeloid, ...

To characterize the biology and optimal therapy of acute mixed-lineage leukemia in children, we reviewed the pathologic and clinical features, including response to therapy, of 35 patients with mixedlineage leukemia. The majority of cases (91%) had blasts cells that simultaneously expressed either T-lineage plus myeloid markers (T/myeloid, n 20) or B-lineage plus myeloid markers (B/myeloid, n 1...

The objectives of this review were to discuss standard and investigational treatment strategies for adolescent and young adult with acute myeloid leukemia, excluding acute promyelocytic leukemia. Acute myeloid leukemia (AML) in adolescent and young adult patients (AYAs) may need a different type of therapy than those currently used in children and older patients. As soon as AML is diagnosed, AY...

Myeloid leukemias are a broad group of hematological disorders, characterized by heterogeneous clinical and biological features. In recent years, unprecedented genetic discoveries clinical–biological correlations have revolutionized the field myeloid leukemias. The most relevant changes specifically occurred in acute leukemia (AML), chronic myelomonocytic (CMML), (CML) neoplasms (MNs) with eosi...

Authors Yasmin Nabil El-Sakhawy, Shaimaa Abdelmalik Pessar, Noha Hussein Boshnak Ain Shams University Egypt Corresponding Author Yasmin Nabil El-Sakhawy Email: [email protected], Mobile: 1005276531 Abstract Background: CD71 or transferrin receptor is an integral membrane protein that mediates cellular iron uptake. It has been identified as a proliferation marker being expressed on many so...

acute myelogenous leukemia (aml) is a subtype of acute leukemia, which is characterized by the accumulation of myeloid blastsin the bone marrow. careful microscopic examination of stained blood smear or bone marrow aspirate is still the most significantdiagnostic methodology for initial aml screening and considered as the first step toward diagnosis. it is time-consuming and dueto the elusive n...

Introduction: Apoptosis is an important mechanism in both physiological and pathological conditions. The BCL2 family of proteins plays a critical role in regulation of apoptotic cell death. Up and down regulation of BCL2-like 12 (BCL2L12), a new member of the BCL2 family, has been reported in several malignancies. However, the expression level of BCL2L12 rarely has been studied in leukemia. T...

Recently wild-type p53-induced phosphatase was implicated in the pathogenesis of acute myeloid leukemia (AML) and “pre-leukemia” myeloproliferative conditions. Here we decided to check how strategy directed inhibition affected sensitivity conventional chemotherapy. All experiments were conducted on AML cell lines cultivated vitro. The levels vary different lines. chemical compound GSK2830371 re...

Abstract Background The relation between PIM2 and the transcriptional factor NF κβ have been controversial in literature. significance of NF-κβ genes expression on incidence acute leukemia (AML ALL) its relevance to response rate was evaluated. Sixty de novo patients were stratified 2 groups: 30 myeloid (AML) lymphoblastic (ALL) compared sex- age-matched controls. level measured using quantitat...