some of the genotypes of cytokines are associated with acute graft versus host disease after bone marrow transplantation. the purpose of the present investigation was to find out the possible association between transforming growth factor beta-1 (tgf-β1) codon 25 polymorphism (rs:1800471) and acute graft versus host disease (agvhd) after bone marrow transplantation from the sibling with the sim...

myeloid sarcoma of female breast is a rare presentation of acute myeloid leukemia (aml). the tumor mass may precede or occur concurrently with aml, cml, myeloproliferative disorders, and/or myelodysplastic syndromes. histologically, it looks like a large cell lymphoma and can be misdiagnosed. a case referred as a suspected case of large cell lymphoma. initial morphological study with convention...

BACKGROUND Differences in the clinical course of secondary acute myeloid leukemia according to the type of the preceding disorders are not defined. We compared the outcomes of therapy-related acute myeloid leukemia, acute myeloid leukemia following myelodysplastic syndrome and acute myeloiod leukemia following myeloproliferative neoplasm. We also intended to find prognostic factors in secondary...

The ex vivo sensitivity of pediatric leukemia cells to the proteasome inhibitor bortezomib was compared to 3 next generation proteasome inhibitors: the epoxyketone-based irreversible proteasome inhibitors carfilzomib, its orally bio-available analog ONX 0912, and the immunoproteasome inhibitor ONX 0914. LC50 values were determined by MTT cytotoxicity assays for 29 childhood acute lymphoblastic ...

introduction: about half of acute myeloid leukemia (aml) adult patients have no cytogenetic abnormalities as a main determinant of complete remission after treatment, so other markers are needed such as flt3-itd (fms-like tyrosine kinase3-internal tandem duplication) mutations in patients with normal karyotype. the objective of this study was assessing the frequency of flt3-itd mutations and it...

BACKGROUND Acute myeloid leukemia is typically a disease of the older population and presents mostly in the fifth decade of life. Myeloid sarcoma is a rare initial presentation of acute myeloid leukemia. Previously it has only been documented in children and younger patients. CASE PRESENTATION We present an unusual case of retro-orbital myeloid sarcoma as an initial presentation of acute myel...

post-remission treatment in patients with acute myeloid leukemia is still controversial. one potent choice for patients with no donor available is autologous stem cell transplantation. the median follow-up period was 18 months and the median age was 26 years old. in the review of 116 recently diagnosed aml patients (except aml- m3) who underwent autologous stem cell transplantation, 72.4% of pa...

introduction: allogeneic hematopoietic stem cell transplantation (hsct) has been reported to be a successful curative treatment in aml patients. myeloablative conditioning (mac) is used more frequent as a preparing regimen. this study attempts to compare the outcome of patients who has received mac and reduced- intensity conditioning (ric). methods: totally, 618 patients with aml underwent hsct...

necrotizing fasciitis is a part of a spectrum of necrotizing soft tissue infections that usually follow a surgical intervention or a chronic / acute medical illness. diagnosis is often based on symptoms which classically start within hours after an injury. there are no reports on the use of pet/ct in this condition. sparing reports of its association in patients with malignancy (ca of colon and...

introduction: the majority of leukemia patients are acute leukemia patients, so that about 70.8% lymphoblastic leukemia were acute lymphoblastic leukemia (all) patients and 66.4 % of myeloid leukemia patients were acute myeloid leukemia (aml) in tehran metropolitan. during the last two decades, intensification of therapy by the use of high-dose cytarabine allogeneic stem cell transplantation in...