Background: Acute promyelocytic leukemia (APL) is a unique subtype of acute leukemia’s. It has distinct Cytogenetics, clinical features, and biologic characteristics. Acute promyelocytic leukemia (APL) is caused by an arrest of leukocyte differentiation at the promyelocytic stage. The discovery and elucidation of the molecular pathogenesis for APL has led to first and only targeted therapy for ...

In the human promyelocytic cell line HL60, we observed both a strong procoagulant activity (PCA) on the cell membrane and proteolytic activity in the lysate of these cells. Because these cell-line cells are susceptible to differentiation to either a more mature granulocytic or monocytic form, we were able to study the hypothesis that the combination of PCA and proteolytic activity is confined t...

Briefly, the important clinical findings were as follows: A 10 year old white girl, acutely ill, febrile and showing disseminated skin purpura. There was no visceromegaly. The disease had apparently started 3 weeks before, with epistaxis and other purpuric manifestations. Laboratory findings showed severe anemia and thrombocytopenia with a leukocyte count of 3500 per cu. mm. The differential co...

Sai-Juan Chen, * Arthur Zelent, * Jian-Hua Tong, * Huai-Qin Yu, * Zhen-Yi Wang, * Josette Derre,1 Roland Berger,' Samuel Waxman,11 and Zhu Chen* *Shanghai Institute ofHematology, Rui-Jin Hospital, Shanghai Second Medical University, and Shanghai Central Railway Hospital, Shanghai 200025, China; *Leukaemia Research Fund Center at the Institute ofCancer Research, Chester Beatty Laboratories, Fulh...

Acute promyelocytic leukemia (APL) is typified by t(15;17)(q22;q21), generating the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The PML-RARA fusion gene is believed to play a vital role in leukemogenesis. A sizeable minority of patients with complex variants of APL have been reported. The present study reports the case of a 33-year-old male...