We have established a murine model and techniques with which to serially study thrombocytopoiesis after induction of experimental immune thrombocytopenia of variable severity and duration. Bone marrow megakaryocyte ploidy distribution was determined by using unfractionated bone marrow, a polyclonal megakaryocyte-specific probe, and two-color, fluorescence-activated flow cytometry. With these te...

Penile necrosis is a rare condition that has been mostly described in association with diabetes mellitus and end-stage renal disease. We report an unusual case of acute penile necrosis because of heparin-induced thrombocytopenia. A 75-year-old man presented with acute renal failure and experienced cardiac complications during the hospitalization. The patient was treated twice with intravenous h...

A 51-year-old woman with adenomyosis was admitted because of anemia with schistocytosis, thrombocytopenia, and acute renal failure (ARF). Thrombotic microangiopathy (TMA) was considered. Plasma exchange and steroid therapies improved laboratory results. However, renal biopsy specimen revealed acute tubular necrosis (ATN), but not TMA, and thrombocytopenia, diagnosed it as disseminated intravasc...

BACKGROUND Anorexia nervosa (AN) is a difficult-to-treat psychosomatic disease. Very few cases of acute liver failure associated with AN have been described. We describe one patient who was affected by AN and presented high level increase of serum liver enzymes, along with sever thrombocytopenia. Then, we discuss the possible etiopathogenic factors. METHODS A 14-year-old boy with AN was admit...

We studied thrombocytopenia during acute Plasmodium falciparum malaria in 64 traveller children from Paris (France), 85 children from Dakar (Senegal) with an intermittent exposure (69 with severe attack or cerebral malaria), and 81 children from Libreville (Gabon) with a perennial exposure (43 with severe attack or cerebral malaria). Initial thrombocytopenia was present in 43-58% of children wi...

OBJECTIVE To identify the haematological causes of thrombocytopenia in children admitted at a tertiary care hospital. METHODS The prospective, descriptive study was carried out at the Aga Khan University Hospital, Karachi, from September 3, 2009 to March 3, 2010, and comprised children between one month and 14 years of age with platelet count less than15000. After reviewing the record, a ques...

A 56-year-old male with a poorly controlled human immunodeficiency virus infection presents to the emergency room due anorexia and weight loss. The patient was emaciated, hypertensive his laboratory tests showed thrombocytopenia, anaemia, an elevated lactate dehydrogenase acute kidney injury. admitted Infecciology ward by fourth day, as function did not improve, Nephrology consultation requeste...

Malarial parasites are expected to induce haematological alterations but reports on changes in haematological parameters during malaria among adults in Southwest Nigeria are not well documented. To investigate the effect of acute malaria on some haematological indices, a sample of 5 ml of venous blood was drawn from each of 671 adults with acute malarial infection and 523 apparently healthy sub...