Phenomena in the performance behaviour of high-performance computing (HPC) applications can stem from the HPC system itself, from the application’s code, but also from the simulation domain. In order to analyse the latter phenomena, we propose a system that visualizes profile-based performance data in its spatial context, i.e., on the geometry, in the simulation domain. It thus helps HPC expert...

Çokanlamlılığın temel unsurlarından olan anlam aktarımları, bağlam içerisinde güçlü ve etkileyici bir anlatım gerçekleştirmek amacıyla kelimelerin yeni anlamlar kazanmasıyla meydana gelen olaylarıdır. Anlam değişmelerine yol açtığı için de dilbilimcilerin üzerinde araştırma yaptığı konu olmuştur. Reisig Breal’in çalışmalarından itibaren anlambilim çalışmaları yer almış deyim aktarmaları (metafo...

Four human B cell lines established by Epstein-Barr viral transformation of B cells from a patient with a clinical diagnosis of Alzheimer's disease (AD) were found to secrete antibodies that react with plaques and cerebrovascular blood vessels in AD brain in a staining profile characteristic of beta-amyloid protein (beta-AP) in AD brain. Two of these antibodies were shown to be reactive with a ...

BACKGROUND Caregivers of patients with mild cognitive impairment (MCI) need similar levels of support services as Alzheimer's disease (AD) caregivers, but it is unclear if this translates to increased caregiver burden. METHODS 135 participants and their caregivers (40 MCI, 55 AD and 40 normal controls, NC) completed questionnaires, and the patients were administered neuropsychological tests. ...

Introduction Mild Cognitive Impairment (MCI), a disorder of the elderly people, is difficult to diagnose and often progresses to Alzheimer Disease (AD). Temporal region is one of the initial areas, which gets impaired in the early stage of AD. Therefore, auditory cortical evoked potential could be a valuable neuromarker for detecting MCI and AD. Methods In this study, the thresholds of Audito...

Neuroinflammation is a key feature of Alzheimer's disease (AD), progressive neurodegenerative disorder. Microglia, the resident immune cells central nervous system, play crucial role in pathogenesis AD and are active participants neuroinflammation. Adequate reproduction neuroinflammation animal models one main methodological approaches for studying pathophysiology. The aim study was to conduct ...

The diagnosis of idiopathic normal pressure hydrocephalus (iNPH) is sometimes complicated by concomitant Alzheimer's disease (AD) pathology. The purpose of the present study is to identify an iNPH-specific cerebrospinal fluid (CSF) biomarker dynamics and to assess its ability to differentiate iNPH from AD. Total tau (t-tau), tau phosphorylated at threonine 181 (p-tau), amyloid-β (Aβ) 42 and 40,...

BACKGROUND Preclinical prediction of Alzheimer disease (AD) is important and critical to effective intervention. Plasma levels of amyloid-β (Aβ) peptides have been a principal focus of the growing literature on blood-based biomarkers, but studies to date have varied in design, assay methods, and sample size, making it difficult to readily interpret the overall data. OBJECTIVE To conduct a sys...

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder characterized by amyloid accumulation, neuronal death, and cognitive impairments. Yi-Chi-Tsung-Ming-Tang (YCTMT) is a traditional Chinese medicine and has never been used to enhance cognitive function and treat neurodegenerative disorders such as senile dementia. Whether YCTMT has a beneficial role in improving learning and ...