ownload isintegrin and metalloproteinase-12 (ADAM-12), a member of multifunctional family of proteins, is lated in many cancers, including breast, lung, liver, prostate, gastric, and bladder. The multidomain re, composed of a prodomain, a metalloproteinase, disintegrin-like, epidermal growth factor–like, cysteined transmembrane domains, and a cytoplasmic tail, allows ADAM-12 to promote matrix d...

The selection of the optimizer is critical for convergence in field on-chip training. As one second moment optimizer, adaptive estimation (ADAM) shows a significant advantage compared with non-moment optimizers such as stochastic gradient descent (SGD) and first-moment Momentum. However, ADAM hard to implement on hardware due computationally intensive operations, including square, root extracti...

John Kriesel, MD; Bryce Moulton; Cammie Barrus NP; Michael Vaughn, BS; Robert Crisp, PhD; Infectious Diseases, University of Utah School of Medicine, Salt Lake City, UT; Infectious Diseases, University of Utah, Salt Lake City, UT; Salt Lake Valley Health Department, Salt Lake City, UT; Biofire Diagnostics, LLC, Salt Lake City, UT; Research and Development/Biochemistry, Biofire Diagnostics, LLC,...

Eliza Rybska, Zbigniew Adamski 2, 3 Antoni Wójcik and Jerzy Błoszyk 5, 6 The Faculty Laboratory for Teaching Biology and Natural Science. Faculty of Biology, Adam Mickiewicz University, Poznan, Poland, Electron and Confocal Microscope Laboratory/ Department of Animal Physiology and Developmental Biology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland Quantum Electronics Laborato...

One of the narrative strategies employed in different ways by men and women writers is the presentation of narrator. The significance of narrator is so much that it differentiates between the realistic and non-realistic fiction and specifically men's and women's writings in realistic fiction. Robyn R Warhol's theory based on Genette's is applied to Adam Bede by George Eliot to focus on woman as...

A disintegrin and metalloproteinase domain (ADAM) proteins are a family of transmembrane glycoproteins with heterogeneous expression profiles and proteolytic, cell-adhesion, -fusion, and -signaling properties. One of its members, ADAM-8, is expressed by several cell types including neurons, osteoclasts, and leukocytes and, although it has been implicated in osteoclastogenesis and neurodegenerat...

Adenoviral vectors directing the expression of HB-EGF and ADAM 12S were used to better understand the gene expression profile of cellular reprogramming into BAT-like cells compared to HB-EGF and ADAM 12S transfection. Human epidermoid carcinoma cells (A431) were co-infected with HB-EGF and ADAM 12S adenoviruses, monitored for fluorescence and lipid accumulation for 1-3 weeks. Cells were stained...

Among proteases, metalloproteases are implicated in tissue remodeling, as shown in numerous diseases including allergy. ADAMs (A Disintegrin And Metalloprotease) metalloproteases are implicated in physiologic processes such as cytokine and growth factor shedding, cell migration, adhesion, or repulsion. Our aim was to measure ADAM-12 expression in airway epithelium and to define its role during ...

OBJECTIVES The ADAMs (a disintegrin and metalloproteinase) enzymes compose a family of membrane-bound proteins characterized by their multi-domain structure and ADAM-12 expression is elevated in human non-small cell lung cancers. The aim of this study was to investigate the roles played by ADAM-12 in critical steps of bronchial cell transformation during carcinogenesis. MATERIALS AND METHODS ...

BACKGROUND Inappropriate platelet activation is known to be associated with various thrombotic disorders. Platelet-monocyte aggregates (PMAs), whose formation is mediated by platelet surface P-selectin (CD62P), can be used as a reliable marker to detect platelet activation. Previous studies have generally detected PMAs through flow cytometry-based approaches. Recently, the ADAM(®) image cytomet...