Received:May 18, 2015, Revised:(1st) August 5, 2015, (2nd) October 23, 2015, Accepted:October 23, 2015 Corresponding to:Seung-Cheol Shim, Division of Rheumatology, Department of Medicine, Daejeon Rheumatoid and Degenerative Arthritis Center, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea. E-mail:[email protected] *The first two authors contributed equally to...

BACKGROUND ADAM 33 is the first gene identified as a candidate for asthma by positional cloning techniques, with association studies reaching impressive statistical significance. It has a postulated role in myogenesis, airway modelling, and signalling via protein shedding. Concerns over the methodology of the initial study have led to several attempts at replication, with inconsistent results. ...