A clean process has been developed for the synthesis of 2-adamantylphenol derivatives through adamantylation of substituted phenols with adamantanols catalyzed by commercially available and recyclable ion-exchange sulfonic acid resin in acetic acid. The sole byproduct of the adamantylation reaction, namely water, could be converted into the solvent acetic acid by addition of a slight excess of ...

BACKGROUND An antibiotic-free, fixed-dose combination gel with adapalene (A) 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for treatment of acne vulgaris. OBJECTIVE To compare the clinical outcomes of A-BPO combination gel with vehicle gel for treatment or maintenance therapy of patients with acne vulgaris. METHODS An electronic search of the database PubMed (1966 to September 201...

We present a middle-aged Japanese female case of vulvar and facial syringomas, very rare clinical phenotype the disease, with severe intractable itching. The skin manifestation symptom were unresponsive to topical corticosteroids persisted for more than decade, but her itching dramatically improved adapalene monotherapy. discuss treatment dilemma syringomas pharmaceutical mechanism action satis...