Global Commentary If the findings are validated in future studies, this alternative therapeutic protocol could become the most appropriate for hypoadrenocorticism. The choice of hydrocortisone is rational and scientifically sound because its equipotent mineralocorticoid and glucocorticoid effects make it well-tailored for addressing the hormonal deficits that constitute the hallmark of Addison ...

Background: Mitochondrial diseases are a group of disorders caused by mutations in nuclear DNA or mitochondrial DNA, usually involving multiple organ systems. Primary adrenal insufficiency due to mitochondrial disease is extremely infrequent and has been reported in association with mitochondrial DNA deletion syndromes such as Kearns–Sayre syndrome. Aim: To report a 3-year-old boy with Addison ...