In this paper two different methods are presented to approximate the solution of the fractional Black-Scholes equation for valuation of barrier option. Also, the two schemes need less computational work in comparison with the traditional methods. In this work, we propose a new generalization of the two-dimensional differential transform method and decomposition method that will extend the appli...

E2 enzymes catalyze the ATP-dependent polymerization of polyubiquitin chains which function as molecular signals in the regulation of numerous cellular processes. Here we present a method that uses genetically encoded unnatural amino acids to halt and re-start ubiquitin polymerization providing access to natural-linkage, precision-length ubiquitin chains that can be used for biochemical, struct...

The sophistication of the editing mechanisms that prevent gene translation errors indicates that amino acid misincorporation is generally a problem to be avoided. Mistranslation is considered invariably deleterious and often caused by confusion between similar proteogenic amino acids. These views are being challenged. The evidence linking misincorporation of dietary non-proteogenic amino acids ...

The skin is an important organ, and the need for attention to its metabolic requirements is often underestimated by professionals involved with its integrity and beauty. Amino acids are the indispensable nutritional basis for the maintenance of its integrity. The skin has very peculiar amino acid needs, which should be acknowledged and supplied if necessary.

In the human organism, proteins undertake multiple and vital functions. Structural proteins are found in each and every cellular compartment. Intracellularly, motor proteins power the energy-dependent transportation of vesicles. Signal proteins receive and transmit information. Transport and storage proteins bind, for example, oxygen, and carry it to a location where it is needed. Of equally gr...

The phenomenon of codon usage bias has been important in the study of evolution because it provides examples of weak selection working at the molecular level. During the last two decades, evidence has accumulated that some examples of codon usage bias are driven by selection, particularly for species of fungi (e.g., Bennetzen and Hall 1982; Ikemura 1985), bacteria (e.g., Ikemura 1981; Sharp and...

The goal of pediatricians involved in the nutritional management of preterm infants is to mimic intrauterine growth and to obtain a functional outcome comparable to that for infants born at term. Appropriate administration of nutrients in the first few days to weeks of life will reduce the growth restriction that is frequently observed. Existing guidelines advise providing preterm infants with ...

During the evolution of metazoans and the rise of systemic hormonal regulation, the insulin-controlled class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway was merged with the primordial amino acid-driven mammalian target of rapamycin (mTOR) pathway to control the growth and development of the organism. Insulin regulates mTOR function through a recently described canonical signaling pathway, ...

By using metallo-hydrogel as a new platform, a simple and straightforward selective visual discrimination of cysteine, homocysteine and glutathione from each other as well as from other amino acids has been realized.

Children with mental retardation are often subjected to a routine battery of tests, a practice that has been criticised.' Investigations often include a blood count, a biochemical profile, urinary screening for metabolites including amino acids, and radiography of the skull and wrist for bone age and may be more extensive. Such routine testing of all children with mental retardation is done in ...