Aim: To determine the sensitivity and specificity of pleural fluid ADA for the diagnosis of tuberculous pleural effusion taking the cut off value of ADA as ≥ 40 mg/dl. Methods: It was a prospective, analytical study comprised of 220 patients having pleural effusion. Sputum smear examination and sputum culture for mycobacterium tuberculosis, pleural fluid examination for protein, glucose, cell c...

OBJECTIVES To assess the utility of C-reactive protein (CRP) levels and adenosine deaminase (ADA) activity in the cerebrospinal fluid (CSF) as rapid screening tests to differentiate various types of meningitis in adults and to establish a cut off level for ADA. METHODS CSF samples were obtained from 50 patients who presented to the emergency room and out-patient of Sri Siddhartha Medical Hosp...

Pulmonary fibrosis is a common feature of numerous lung disorders, including interstitial lung diseases, asthma, and chronic obstructive pulmonary disease. Despite the prevalence of pulmonary fibrosis, the molecular mechanisms governing inflammatory and fibroproliferative aspects of the disorder are not clear. Adenosine is a purine-signaling nucleoside that is generated in excess during cellula...

Chronic lymphocytic meningoencephalitis with low glucose and increased adenosine deaminase (ADA) levels in the CSF together with hydrocephalus represents a diagnostic challenge of varied etiology and only seldom is due to a viral (mumps) infection.

Genetic variation of the enzyme, adenosine deaminase (ADA), can be detected by starch gel electrophoresis of human red cell lysates and an appropriate staining procedure (Spencer, Hopkinson, and Harris, 1968). Three phenotypes (ADA 1, ADA 2-1, and ADA 2) appear to be determined by two structural alleles, ADA' and ADA2. The frequency of the less common allele, ADA2, was reported to be 0 03 and 0...

Adenosine acts as anti-inflammatory mediator on the immune system and has been described in regulatory T cell (Treg)-mediated suppression. In the absence of adenosine deaminase (ADA), adenosine and other purine metabolites accumulate, leading to severe immunodeficiency with recurrent infections (ADA-SCID). Particularly ADA-deficient patients with late-onset forms and after enzyme replacement th...

BACKGROUND Tuberculosis kills five lakh patients every year in India, commonest being pulmonary tuberculosis and is often associated with effusion. Delay in diagnosis and treatment results in poor prognosis. Several studies have suggested the role of adenosine deaminase (ADA) in the diagnosis of tuberculous pleural effusions, but false-positive results from lymphocytic effusions have also been ...

Tuberculosis (TB) is one of the oldest and commonest infectious diseases also known as “master of Death”. Pulmonary TB (PTB) and TB with pleural effusion remains a diagnostic challenge. Adenosine deaminase (ADA) is an enzyme of purine catabolism which is an inexpensive and easy test in early routine evaluation of patients with pleural effusion. Aim: To assess the diagnostic level of ADA in TB p...

Deficiency of erythrocytic and lymphocytic adenosine deaminase (ADA) occurs in some patients with severe combined immunodeficiency disease (SCID). SCID with ADA deficiency is inherited as an autosomal recessive trait. ADA is markedly reduced or undetectable in affected patients (homozygotes), and approximately one-half normal levels are found in individuals heterozygous for ADA deficiency. The ...

Genetic variation of the enzyme, adenosine deaminase (ADA), can be detected by starch gel electrophoresis of human red cell lysates and an appropriate staining procedure (Spencer, Hopkinson, and Harris, 1968). Three phenotypes (ADA 1, ADA 2-1, and ADA 2) appear to be determined by two structural alleles, ADA' and ADA2. The frequency of the less common allele, ADA2, was reported to be 0 03 and 0...