Aim: To assess the attitudes and perceptions of medical practitioners towards adverse drug reaction (ADR) reporting and factors that influence the reporting of ADR. Method: A suitable self-administered survey questionnaire was designed and randomly circulated to 110 doctors in three different hospitals where local hospital based ADR reporting system exist. Results: A total of 97 filled question...

A considerable percentage of Internet Things end-devices are characterised by mobility, a feature that adds extra complexity to protocols used in Wireless Sensor Networks. LoRa is one the newly introduced wireless sensor protocols, capable delivering messages long distances and consuming low energy, features make it proper for cost devices. Although was as technology stationary devices, can als...

The application of chemotherapeutic drug adriamycin (ADR) in cancer therapy is limited by its side effects like high toxicity and insolubility. Nanomedicine offers new hope for overcoming the shortcomings. But how to increase in vivo stability and to control intracellular drug release is a key issue for nano-based formulations. Herein, the hydrophobic ADR was successfully linked to the biocompa...

Studies of the biological chemistry of most anticancer drugs have revealed their cytotoxicity is expressed after the drugs have entered cells. It is thought that anthracycline antitumor drugs exert their cytotoxicity by entering cells, diffusing into nuclei, and inhibiting topoisomerase II and/or intercalating DNA base pairs. In order to deliver anthracyclines to transferrin (TRF) receptors on ...

Here we take advantage of the well-characterized and simple nervous system of Caenorhabditis elegans to further our understanding of the functions of RNA editing. We describe the two C.elegans ADAR genes, adr-1 and adr-2, and characterize strains containing homozygous deletions in each, or both, of these genes. We find that adr-1 is expressed in most, if not all, cells of the C.elegans nervous ...

Background—The precise molecular mechanism of Adriamycin-induced cardiomyopathy (ADR-CM) is still unknown. We address the demonstration of apoptotic myocardial cell death and the apoptosis-inducing molecules in ADR-CM induced in rats. Methods and Results—Until 8 weeks after the first administration of ADR, there was no increase in the number of labeled cells by terminal deoxynucleotidyl transfe...

Adrenal sympathetic preganglionic neurons (ADR SPNs) regulating the chromaffin cell release of epinephrine (Epi ADR SPNs) and those controlling norepinephrine (NE ADR SPNs) secretion have been distinguished on the basis of their responses to stimulation in the rostral ventrolateral medulla, to glucopenia produced by 2-deoxyglucose, and to activation of the baroreceptor reflex. In this study, we...

Alternative Dispute Resolution (ADR) is now widely used around the world to deal with disputes and conflicts as well as agreement-making and planning. Forms of ADR initially developed in many countries often supported thirdparty decision-making and therefore tended to be more advisory or decisional and less facilitative (for example, arbitral forms of ADR were introduced in many jurisdictions b...

BACKGROUND Heparanase, an endoglycosidase that cleaves heparan sulfate (HS), is involved in various biologic processes. Recently, an association between heparanase and glomerular injury was suggested. The present study examines the involvement of heparanase in the pathogenesis of Adriamycin-induced nephrotic syndrome (ADR-NS) in a mouse model. METHODS BALB/c wild-type (wt) mice and heparanase...