The potential role of adrenergic systems in regulating Na(+) uptake in zebrafish (Danio rerio) larvae was investigated. Treatment with isoproterenol (a generic β-adrenergic receptor agonist) stimulated Na(+) uptake, whereas treatment with phenylephrine (an α(1)-adrenergic receptor agonist) as well as clonidine (an α(2)-adrenergic receptor agonist) significantly reduced Na(+) uptake, suggesting ...

We examined in conscious dogs the effects of /9-adrenergic receptor blockade on measurements of left circumflex coronary arterial diameter and blood flow and calculations of late diastolic coronary resistance and left circumflex coronary internal cross-sectional area. Propranolol (combined /3iand 02-adrenergjc receptor blockade) and atenolol (selective /Stadrenergic receptor blockade) elicited ...

Alzheimer disease features amyloid-β (Aβ) peptide deposition in brain and blood vessels and is associated with hypertension. Aβ peptide can cause vasoconstriction and endothelial dysfunction. We observed that Aβ peptides exert a chronotropic effect in neonatal cardiomyocytes, similar to α1-adrenergic receptor autoantibodies that we described earlier. Recently, it was shown that α1-adrenergic re...

Increased sympathoadrenal activity appears to play an important role in the development or maintenance of elevated blood pressure in hypertensive patients and various animal models of hypertension. Alterations of adrenergic receptor number or responsiveness might contribute to this increased activity. We therefore reviewed the data on adrenergic receptor alterations in hypertension with special...

A procedure has been developed for purification of the porcine brain alpha 2-adrenergic receptor to homogeneity. alpha 2-Adrenergic receptors were solubilized from porcine brain particulate preparations using sequential extraction into sodium cholate- and digitonin-containing buffers. The alpha 2-adrenergic receptors in the digitonin extract were identified using the alpha 2-adrenergic selectiv...

The various subtypes of receptors for catecholamines, termed adrenergic receptors, represent excellent models for the study of receptor-mediated transmembrane signalling because of their ubiquity, their coupling to well-defined effector mechanisms, and the clinical importance of drugs which interact with them. In general, the adrenergic receptor systems consist of three components which are cou...

Philipp, Melanie, Marc Brede, and Lutz Hein. Physiological significance of 2-adrenergic receptor subtype diversity: one receptor is not enough. Am J Physiol Regulatory Integrative Comp Physiol 283: R287–R295, 2002; 10.1152/ajpregu.00123.2002.— 2-Adrenergic receptors mediate part of the diverse biological effects of the endogenous catecholamines epinephrine and norepinephrine. Three distinct sub...

We tested the hypothesis that a genetically determined increase in renal alpha-adrenergic receptor density might be a pathophysiologically important factor in the spontaneously hypertensive rat model of genetic hypertension. In a first study, we compared renal alpha 1 and alpha 2-adrenergic receptor density with systolic blood pressure in 45 rats of an F2 generation of Wistar-Kyoto x spontaneou...

The Madin-Darby canine kidney (MDCK) cell line, derived from distal tubule/collecting duct, expresses differentiated properties of renal tubule epithelium in culture. We studied the expression of adrenergic receptors in MDCK to examine the role of catecholamines in the regulation of renal function. Radioligand-binding studies demonstrated, on the basis of receptor affinities of subtype-selectiv...