OBJECTIVE In this work, role of the adrenergic nerve system (alpha1 and beta2) in adjustment of the bronchomotor tonus in healthy people was researched. METHODS Parameters of the lung function are determined by Body plethysmography. Raw and ITGV were registered and SRaw was calculated as well. Aerosolization is done with standard aerosolizing machines - Asema. RESULTS Results gained shows t...

Circulation Research is available at http://circres.ahajournals.org DOI: 10.1161/CIRCRESAHA.113.300308 Abstract: Heart failure (HF), the leading cause of death in the western world, develops when a cardiac injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It is characterized by a complex interplay of several neurohormonal mechanisms that become activ...

Activation of the adrenergic system has a profound effects on metabolism. Increased circulating catecholamine and activation of the different adrenergic receptors deployed in the various organs produce important metabolic responses which include: (1) increased lipolysis and elevated levels of fatty acids in plasma, (2) increased gluconeogenesis by the liver to provide substrate for the brain, a...

the association between β2-adrenergic receptor (adrb2) -16arg/gly polymorphism (rs1042713) and chronic obstructive pulmonary disease (copd) risk has been investigated in many published studies. however, the results were inconclusive. a meta-analysis was performed to make a more precise estimation of the relationship.the pubmed, embase, isi web of science, the cochrane database of systematic rev...

The influence of the adrenergic system on the population of ventricular myosin isoenzymes under physiological conditions was assessed by subjection of normotensive and spontaneously hypertensive rats (SHR) to different types of physical exercise that increased the activity of the peripheral adrenergic system to varying degrees. The routines, which were 5-6 weeks in duration, involved the mild e...

THE CONCEPT that drugs react with specific receptors in living tissues to produce pharmacologic effects is believed to have originated with Langley in 19051 although Ehrlich and others had certainly conceived of specific drug-cellular interactions. Today receptors have achieved such status amnong pharmacologists to be almost commonplace in spite of the fact that their identity has not been esta...

THE CONCEPT that drugs react with specific receptors in living tissues to produce pharmacologic effects is believed to have originated with Langley in 19051 although Ehrlich and others had certainly conceived of specific drug-cellular interactions. Today receptors have achieved such status amnong pharmacologists to be almost commonplace in spite of the fact that their identity has not been esta...

C ongestive heart failure is associated with pronounced alterations in adrenergic nervous system function. Levels of myocardial norepinephrine are decreased, as first reported in 1963,1 a phenomenon later found to be associated with increased sympathetic nervous system activation and high levels of circulating plasma catecholamines2 in combination with abnormalities in neural reuptake of norepi...