INTRODUCTION The Masimo Radical-7 Pulse CO-Oximeter is a medical device recently approved by the US Food and Drug Administration that performs noninvasive oximetry and estimated venous or arterial hemoglobin measurements. A portable, noninvasive device that rapidly measures hemoglobin concentration could be useful in both austere and modern hospital settings. The objective of this study is to d...

The present study was designed to investigate the effect of acute heat stress on some hematological parameters in which young and adult Murrah buffaloes (n=6) were exposed to 40°C, 42°C, 45°C for 4 h duration in climatic chamber and thermoneutral temperature (22°C). Blood samples were collected by jugular vein puncture in sterile vacutainer tubes containing ethylene diamine tetra acetic acid (E...

Wit/i the technical assistance of Anne Council F ETAL HEMOGLOBIN ( Hb F) is the major respiratory pigment formed during intrauterine life. In the adult, however, only trace concentrations normally are present. In man there are at least two distinct conditions in which genetic factors cause elevated levels of Hb F in adult life. They are the hereditary persistence of fetal hemoglobin syndromes a...

Rabbit antibodies specific for the major tadpole and frog hemoglobin components of R. catesbeiana were used for the detection of the two hemoglobins inside single cells . The antisera, after fractionation by ammonium sulfate precipitation and diethylaminoethyl (DEAE)cellulose chromatography, were conjugated with fluorescein isothiocyanate for the antifrog hemoglobin serum and tetramethylrhodami...

IN PREVIOUS CO? -IMUNICATIONS’-3 the hematologic effects of the gene for an abnormal hemoglobin, since designated as hemoglobin C, were described in two combinations: A-C, an asymptomatic carrier state in which the hemoglobin consists of a mixture of A (normal adult type) hemoglobin amid C; secondly S-C, a variant of sickle cell disease in which sickle hemoglobin S is produced together with hem...

AND MORTIMER GARRISON, JR. T HERE IS considerable interest currently with respect to the acid elution metho)d of Kleihauer, Braun and Betke1 for detecting cytologically those circulating erythrocytes which have an appreciable content of fetal hemoglobin (“F-containing cells” ) . The method is based on the lower solubility of alkaliresistant or fetal hemoglobin in an acid environment as compared...

Hydroxyurea is used for sickle-cell disease patients in order to increase fetal hemoglobin synthesis and consequently decrease the severity of pain episodes. Fetal hemoglobin, which is formed by gamma-globin chains A and G, is present in a constant composition throughout fetal development: about 75% of Ggamma and 25% of Agamma. In contrast, adult red cells contain about 40% of Ggamma and 60% of...

BACKGROUND Human induced pluripotent stem cells offer perspectives for cell therapy and research models for diseases. We applied this approach to the normal and pathological erythroid differentiation model by establishing induced pluripotent stem cells from normal and homozygous sickle cell disease donors. DESIGN AND METHODS We addressed the question as to whether these cells can reach comple...