growing evidence suggests that serotonin plays an important role in learning and memory and all its receptors might be implicated in this process. the present study aimed at investigating and comparing the possible involvement of 5-ht 3 and 5-ht 4 receptor (r) agonists/antagonists upon consolidation of inhibitory avoidance memory in the pre-limbic (pl) area. bilateral intra-pl microinjections o...

Immunotherapy has had a limited clinical benefit in pancreatic ductal adenocarcinoma (PDAC). In pre-clinical mouse model of PDAC treated with glucocorticoid-induced TNFR-related protein (GITR) agonist, the tumours showed nondurable and heterogeneous responses to GITR agonist. We hypothesised that resistance agonist is associated unique symbiotic interaction between persistent emergent tumour cl...

Tirzepatide (Mounjaro) is a dual GLP-1/GIP receptor agonist for the treatment of type 2 diabetes in adults. This article discusses its administration, clinical trial efficacy and adverse effects.

Introduction: Previous studies have shown that ghrelin inhibits the activity of Hypothalamus –Pituitary – Thyroid (H–P-T) axis. It is also proved that ghrelin increases appetite via Agouti Related Protein and neuropeptide Y pathway, decreases T3 & T4 secretion and inhibits serotonin release from hypothalamic synaptosomes. Serotonin may interact with ghrelin in control of thyroid hormones secr...

The goal of ovarian Stimulation for assisted reproductive technologies (ART) is obtaining multifollicular growth ovarian hyper stimulation syndrome (OHSS) is one of the most Severe and also potentially Life-threatening complications, which happens in 1-10% of IVF cycles. The most common risk factors which are related to OHSS are polycystic ovarian syndrome (PCOS), younger age, high preovulatory...

Full agonist-mediated activation of free fatty acid receptor 1 (FFAR1/GPR40) alleviates diabetes in rodents. Considering that is a chronic disease, assessment treatment durability exposure to GPR40 full agonist pivotal for treating patients with diabetes. However, the physiologic significance vitro and vivo agonists largely unclear. Here, we evaluated effects SCO-267, agonist, on signal transdu...

Responses to partial agonist TCR signals include positive selection of thymocytes, survival of naive T cells, and homeostatic proliferation. As part of an effort to understand the molecular basis of these processes, we have determined how agonist and partial agonist ligands act differently to induce a change in gene expression. We have found that the early growth response gene 1 (Egr1) promoter...

The G protein-coupled estrogen receptor (GPER, nomenclature as agreed by the NC-IUPHAR Subcommittee on [26]) was identified following observations of estrogen-evoked cyclic AMP signalling in breast cancer cells [2], which mirrored differential expression an orphan 7-transmembrane GPR30 [6]. There are both cell-surface and intracellular GPER [29, 34]. Selective agonist/ antagonists for have been...

Abstract Agonist bias occurs when different ligands produce distinct signalling outputs acting at the same receptor. However, its physiological relevance is not always clear. Using primary human cells and gene editing techniques, we demonstrate endogenous agonist with consequences for calcitonin receptor-like receptor, CLR. By switching receptor-activity modifying protein (RAMP) associated CLR ...

Currently, the occurrence of diseases in digestive system swine has increased. Environmental stress and gastric bacteria were associated with body imbalance ulcer, which are related to pathological changes stomach. This study aimed investigate stomach histological characteristics beta-agonist free, hygienic, natural different farming methods. Three types swine’s stomachs bought from three farms...