Corresponding Author: Fatemeh Moradian Assistant professor of Biochemistry, Basic Sciences Group, Sari Agricultural Sciences and Natural Resources University, Sari, Mazandaran, Iran, P.O.B. 578. Telefax:+98-11-33687655 E-mail: [email protected] & [email protected] Abstract Background: Lactoferrin is a glycoprotein with a molecular weight of 80 kDa, as a member of the transferring family. In...

Objectives Cucurbitacins exhibit a range of anti-cancer functions. We investigated the effects of cucurbitacins D, E, and I purified from Ecballium elaterium (L.) A. Rich fruits on some apoptotic and autophagy genes in human gastric cancer cell line AGS. Materials and Methods Using quantitative reverse transcription PCR (qRT-PCR), the expression of LC3, VEGF, BAX, caspase-3, and c-MYC genes w...

BACKGROUND Calprotectin is cytotoxic agent that its anti-tumor effects are governed through suppression of topoisomerase II; a key enzyme in apoptosis. In previous studies, cytotoxicity and apoptotic effects of calprotectin are shown on different cancer cell lines, but not human gastric cancer cell lines. In the present study, cytotoxicity and apoptotic effects of calprotectin on human gastric ...

Gastric cancer (GC) is one of the most frequent types around world and drugs which are used currently as anti-cancer chemotherapy hold adverse side effects on normal cells tissues, that calls for a strong need to find new agents prevent treat GC. Extracts from certain plants contain compounds with health potentials minimal effects; such plant Crataegus azarolus commonly called hawthorn. hawthor...

BACKGROUND & OBJECTIVE Sodium butyrate (NaBT) can inhibit proliferation and induce differentiation of various tumor cells. This study was to investigate effects of NaBT on the proliferation and differentiation of human gastric carcinoma cell line AGS and explore the possible mechanism. METHODS AGS cells were treated with 0, 1.0, 2.0 and 4.0 mmol/L of NaBT. Cell proliferation was detected by M...

shiga toxins (stxs) are bacterial virulence factors produced by shigella dysenteriae serotype 1 and escherichia coli strains. stxs are critical factors for the development of diseases such as severe bloody diarrhea and hemolytic uremic syndrome. additionally, stxs trigger the secretion of pro- inflammatory cytokines and chemokines, particularly in monocytes or macrophages. the inflammatory cyto...

BACKGROUND Although the incidence of gastric cancer is declining during the last half century, this cancer still is the second morbid cancer in the world after lung cancer. The incidence of gastric cancer is 26 per 100,000 in Iran. This study evaluated the effect of Alpinia galangal on AGS cells (human gastric adenocarcinoma epithelial cell line) and L929 cells (as a standard cell line originat...