To optimize antigen delivery by Salmonella vaccine strains, a system for surface display of antigenic determinants was established by using the autotransporter secretion pathway of gram-negative bacteria. A modular system for surface display allowed effective targeting of heterologous antigens or fragments thereof to the bacterial surface by the autotransporter domain of AIDA-I, the Escherichia...

The number of scientific articles has grown rapidly over the years and there are no signs that this growth will slow down in the near future. Because of this, it becomes increasingly difficult to keep up with the latest developments in a scientific field. To address this problem, we present here an approach to help researchers learn about the latest developments and findings by extracting in a ...

The influence of the blockade of group I metabotropic glutamate receptors (mGluRs) by AIDA [(RS)-1-aminoindan-1,5-dicarboxylic acid] on some behavioral effects was tested in control groups of rats and in rats that underwent short-term hypoxia. We used the following methods: the open field test, the passive avoidance test and the elevated "plus" maze test. In rats without hypoxia, AIDA (100 nmol...

Motivation: We address the following question: Does inhibition of the expression of a gene X in a cellular assay affect the expression of another gene Y? Rather than inhibiting gene X experimentally, we aim at answering this question computationally using as the only input observational gene expression data. Recently, a new statistical algorithm called Intervention calculus when the Directed ac...

The present study established a rat cortical neuronal model of in vitro mechanical injury. At 30 minutes after injury, the survival rate of the injured cortical neurons was decreased compared with normal neurons, and was gradually decreased with aggravated degree of injury. Reverse transcription-polymerase chain reaction results showed that at 1 hour after injury, there was increased expression...

The efficiency and service quality in a medical environment can be improved by using electronic documents (or e-docs) and digital signatures to speed up both doctors’ activity and to provide in the same time easy retrieval and use of needed data without loosing convenience. Our proposed solution satisfies these needs by making use of the AIDA system and many cutting-edge techniques to build a d...

The Asteroid Impact & Deflection Assessment (AIDA) mission will be the first space experiment to demonstrate asteroid impact hazard mitigation by using a kinetic impactor to deflect an asteroid. AIDA is an international cooperation, consisting of two mission elements: the NASA Double Asteroid Redirection Test (DART) mission and the ESA Asteroid Impact Mission (AIM) rendezvous mission. The prima...

The aim of this article is to develop an interaction theory (IT) of social cognition. The central issue in the field of social cognition has been theory of mind (ToM), and there has been debate regarding its nature as either theory-theory or as simulation theory. Insights from phenomenology have brought a second-person perspective based on embodied interactions into the debate, thereby forming ...

The purpose of this paper is to report a pilot survey about why people are downloading the AIDA interactive educational diabetes simulator. AIDA is a diabetes computer program that permits the interactive simulation of plasma insulin and blood glucose profiles for teaching, demonstration, and self-learning purposes. It has been made freely available, without charge, on the Internet as a noncomm...

This column continues the report of a detailed, questionnaire-based, post-release feedback survey of 200 users of the AIDA version 4 educational diabetes simulator. AIDA is a software program—available without charge from www.2aida.org—that permits the interactive simulation of plasma insulin and blood glucose profiles for educational, demonstration, self-learning, and research purposes. The ma...