We report a combined photoelectron spectroscopy and theoretical study of the structural evolution of aluminum cluster anions doped with two gold atoms, Au2Aln − (n = 3−11). Well-resolved photoelectron spectra have been obtained at several photon energies and are used to compare with theoretical calculations to elucidate the structures of the bimetallic clusters. Global minima of the Au2Aln − cl...

The marked increase in the incidence of overweight and obese persons is recognized as one of the most serious public health issues in the United States. It is estimated that currently 60% of American adults are overweight and 20% are obese.1 Overweight and obesity are associated with a significantly increased mortality from atherosclerotic cardiovascular disease and other causes.2–4 Although ob...

four days and, before this, diazepam 5-10 mg thrice daily and nitrazepam 5 mg at night for seven months. Although fits may occur when larger doses of benzodiazepines are withdrawn, their occurrence after withdrawal of therapeutic doses of this kind is extremely rare.3 A review of published reports has shown only one other case of fits possibly induced by viloxazine; this also occurred during a ...

We read with interest the papers by Schäfer and colleagues1 on the classification of patients with low back and leg pain and the associated study by Walsh & Hall2 on psychological differences between subgroups within this classification scheme. We agree that the time has come for clinicians to seriously consider that leg pain associated with low back pain (LBP) is not a homogenous subgroup unto...

Large clinical trials have demonstrated profound benefits of aldosterone inhibition by spironolactone in patients with heart failure (impaired left ventricle function 40%) and with eplerenone in patients with myocardial infarction.1 The key enzyme in aldosterone production is aldosterone synthase (CYP11B2). CYP11B2 is predominantly expressed in the adrenal gland but is also expressed in the car...

More children die from congenital heart disease (CHD) each year than are diagnosed with cancer. Although CHD is the most common human birth defect, the etiology of the vast majority of CHDs remains unknown. The difficulty in elucidating the molecular and genetic bases for CHD reflects the complex nature of this and other birth defects. Most CHD occurs sporadically, but the recurrence risk in su...

Overweight and hypertension are major risk factors for cardiovascular morbidity and mortality1,2; both are associated with decline in cognitive performance.3,4 We know that exercise is associated with modest reductions in blood pressure (BP) and that weight loss results in even larger, clinically important reductions in BP.5 What we did not know, before a report6 in this issue of Hypertension, ...

Left ventricular hypertrophy (LVH) and fibrosis have received special attention as possible therapeutic targets in preventing cardiovascular complications of hypertension. Suppression of neurohormonal factors that predispose to target organ damage, in addition to blood pressure (BP) reduction, seems to be of importance in modulating cardiac remodeling and fibrosis in hypertensive heart disease....

Research in the past decades has established a key role for the intrauterine environment, especially the maternal nutritional status, in influencing fetal growth and cardiovascular health in the offspring in later life.1 Experimental evidence suggests that the vasculature of the developing fetus may already be compromised by a suboptimal uterine environment.2 Recent data found associations betw...