BACKGROUND Given mounting evidence for adverse effects from excess manganese exposure, it is critical to understand host factors, such as genetics, that affect manganese metabolism. METHODS Archived blood samples, collected from 332 Mexican women at delivery, were analyzed for manganese. We evaluated associations of manganese with functional variants in three candidate iron metabolism genes: ...

BACKGROUND Environmental lead exposure has been found to be associated with an increased risk of hypertension. Individuals vary greatly in susceptibility to lead toxicity, and genetic susceptibility has often been cited as the probable cause for such variation. OBJECTIVE The main objective is to determine the role of the aminolevulinic acid dehydratase (ALAD) gene, which encodes the main carr...

Lead was administered to pregnant rats in drinking water (5 ppm) from day 1 to day 18 or 21 of gestation, at which time the dams and fetuses were sacrificed. The red blood cell count and hemoglobin concentration were significantly lower in the lead-treated fetuses than in untreated controls on day 21 of gestation, but not in the lead-treated dams. The delta-aminolevulinic acid dehydratase (ALAD...

Roels, H. A., Buchet, J. P., Lauwerys, R. R., and Sonnet, J. (1975). British JournalofIndustrial Medicine, 32, 181-192. Comparison of in vivo effect of inorganic lead and cadmium on glutathione reductase system and 8-aminolevulinate dehydratase in human erythrocytes. The activity of 8-aminolevulinate dehydratase (ALAD) of erythrocytes, the lead (Pb-B) and cadmium (Cd-B) concentration in whole b...

PurposeIn kidney transplant, relative change in % donor-derived cell-free DNA (%dd-cfDNA) is superior to absolute thresholds for detection of injury, though lung transplantation a cut-off 1% used as an arbiter acute allograft dysfunction (ALAD). We previously showed that normal dd-cfDNA% level patients >2 years post-lung without injury 0.45% (IQR 0.21 - 0.64) with value 73%. now seek determine ...

A number of X-ray analyses of an enzyme involved in a key early stage of tetrapyrrole biosynthesis are reported. Two structures of human 5-aminolaevulinate dehydratase (ALAD), native and recombinant, have been determined at 2.8 Å resolution, showing that the enzyme adopts an octameric quaternary structure in accord with previously published analyses of the enzyme from a range of other species. ...

UNLABELLED Preoperative noninvasive imaging to estimate the quantity and spatial distribution of protoporphyrin IX (PpIX) accumulation in tumors induced by 5-aminolevulinic acid (ALA) administration is expected to improve the efficacy of ALA-based fluorescence-guided resection and photo- and sonodynamic therapies. PpIX synthesis from exogenous ALA has been reported to be regulated by ALA influx...

Evidence suggests that lead and selected genes known to modify the toxicokinetics of lead--namely, those for the vitamin D receptor (VDR) and delta-aminolevulinic acid dehydratase (ALAD)--may independently influence blood pressure and hypertension risk. We report the relations among ALAD and VDR genotypes, three lead dose measures, and blood pressure and hypertension status in 798 Korean lead w...

Latin America faces unique challenges in the treatment of type 2 diabetes mellitus. The Asociación Latinoamericana de Diabetes (Latin American Diabetes Association, ALAD) brought together medical associations in 17 countries in Latin America to produce a consensus statement regarding the treatment of type 2 diabetes. The goal of the document is to provide practical recommendations that will gui...