Vulvovaginal candidiasis (VVC), caused by Candida albicans, affects women worldwide. Animal and clinical studies suggest that the immunopathogenic inflammatory condition of VVC is initiated by S100 alarmins in response to C. albicans, which stimulate polymorphonuclear neutrophil (PMN) migration to the vagina. The purpose of this study was to extend previous in vitro data and determine the requi...

The comparison of several sequences is central to many problems of molecular biology. Finding consensus patterns that define genetic control regions or that determine structural or functional themes are examples of these problems. Previously proposed methods, such as dynamic programming, are not adequate for solving problems of realistic size. This paper gives a new and practical solution for f...

Previous research suggests that a combination of high need for power, low need for affiliation, and high activity inhibition -the so-called leadership motive pattern (LMP) -is related to high leader effectiveness. However, when studying this relation, research has mainly relied on a typological approach based on dichotomous configurations of motives instead of using a dimensional approach via r...

Negotiating the information-rich sensory world often requires the concurrent management of multiple tasks. Despite this requirement, humans are thought to be poor at multitasking because of the processing limitations of frontoparietal and subcortical (FP-SC) brain regions. Although training is known to improve multitasking performance, it is unknown how the FP-SC system functionally changes to ...

BACKGROUND Alarmins, endogenous molecules released on tissue damage have been shown to play an important role in inflammatory musculoskeletal conditions including fracture repair andrheumatoid arthritis. However, the contribution of alarmins to the pathogenesis of tendon disease is not fully understood. METHODS We investigated expression of alarmin proteins (S100A9, high-mobility group box 1 ...

This paper deals with the circular pattern matching (CPM) problem, which appears as an interesting problem in many biological contexts. CPM consists in finding all occurrences of the rotations of a pattern 𝒫 of length m in a text 𝒯 of length n. In this paper, we present SimpLiFiCPM (pronounced "Simplify CPM"), a simple and lightweight filter-based algorithm to solve the problem. We compare our ...