PURPOSE Primary intraocular lymphoma (PIOL) provides a therapeutic challenge because of its diverse clinical picture and variable clinical course. The main objective of this study was to evaluate the retinal permeability of methotrexate for rabbit and human eyes and then investigate its kinetics in a human eye following the standard induction-consolidation-maintenance (I-C-M) injection protocol...

PURPOSE Intracameral cefuroxime was found to lower the risk of endophthalmitis after cataract surgery. The purpose of this study was to evaluate the retinal toxicity of cefuroxime in a rabbit model. METHODS Twenty-two albino rabbits were divided into two cefuroxime groups: low-dose (1mg/0.1 mL, n = 9) and high dose (10 mg/0.1 mL, n = 13). The right eye of each rabbit was injected with 0.1 mL ...

&&v,w To assess the penetration of Iossrtan and L-158,338 into the rabbit eye after topical application and their effects on the IOP of ocular hypertensive cynomolgus monkeys. M&Q& Penetration was indirectly assessed in albino rabbits using an & assay. Aliquots of aqueous humor were sampled one hour after the bilateral topical instillation of one drop (50 uL) of 2% solutions of losartsn or L-15...

&&v,w To assess the penetration of Iossrtan and L-158,338 into the rabbit eye after topical application and their effects on the IOP of ocular hypertensive cynomolgus monkeys. M&Q& Penetration was indirectly assessed in albino rabbits using an & assay. Aliquots of aqueous humor were sampled one hour after the bilateral topical instillation of one drop (50 uL) of 2% solutions of losartsn or L-15...

BACKGROUND Isodon rugosus is used in folk Pakistan traditional practices to cure ailments related to gastrointestinal, respiratory and cardiovascular problems. Present study was undertaken to validate these folkloric uses. METHODS A crude methanol extract of the aerial parts of Isodon rugosus (Ir.Cr.) was used for both in vitro and in vivo experiments. The plant extract was tested on isolated...

background: the aim of this study was to evaluate the effect of local injection of human growth hormone (gh) in stimulating cartilage and bone formation in a rabbit model of temporomandibular joint (tmj). materials and methods: in an experimental animal study, 16 male albino new zealand white rabbits aged 12 weeks were divided into two groups: in the fi rst group (7 rabbits) 2 mg/kg/1 ml human ...

In order to improve the frequent dosing regimen reported for the commercial aqueous gatifloxacin eye drops, two new ophthalmic mucoadhesive formulations based on high molecular weight sodium hyaluronate were prepared. The pharmacokinetic profiles outlined showed a strong bioavailability increase for gatifloxacin-hyaluronate formulations with respect to aqueous conventional eye drop. Gatifloxaci...

The accumulation of ferritin by the ciliary epithelium of the adult albino rabbit has been studied by electron microscopy. The experiments have been carried out under in vitro conditions, such that any uptake observed should be the result of passive diffusion of the tracerparticles rather than the product of active metabolic processes. The cells were fixed in osmium tetroxide and embedded in Ar...

The conversion of isopentenyl pyrophosphate to phytoene in Neurospora crassa requires both a soluble and a particulate fraction. Soluble and particulate enzyme fractions obtained from light-treated and dark-grown wild type, albino-1, albino-2, albino-3, and white collar-1 strains were mixed in various combinations, and the activity for conversion of [1-(14)C]isopentenyl pyrophosphate to phytoen...

The content of amino acids in plasma and urine from male albino rabbits was determined by ion-exchange chromatography and compared to values for other species. In general, the amino acids present, in the plasma and urine of rabbits are those commonly found in other species. In contrast to human urine in which t,he cont,ent of hi&dine is usually greater than the two methylated derivatives, the c...