This study was designed to evaluate the neuro-ameliorative effect of red (Morus rubra) and white berry (Morus alba) extracts against Alzheimer ́s disease (AD) in male rats. AlCl3 was administered orally to male albino rats (100 mg/kg/day for 6 weeks) while, berry extracts (300 mg/kg/day for six weeks) was administered orally post AlCl3 administration. The data showed markedly elevation in lipid ...

With the advance in nanomedicine, the present study was conducted to explore the possible therapeutic role of intravenous nano- hydroxyapatite (nano-HAp) into male rats after chronic exposure to aluminum chloride (AlCl3). This exposure interposed DNA fragmentation, apoptosis, alters oxidant/antioxidant status as well as change in content of neurotransmitters. The rats were injected with 100 mg/...

With the advance in nanomedicine, the present study was conducted to explore the possible therapeutic role of intravenous nano- hydroxyapatite (nano-HAp) into male rats after chronic exposure to aluminum chloride (AlCl3). This exposure interposed DNA fragmentation, apoptosis, alters oxidant/antioxidant status as well as change in content of neurotransmitters. The rats were injected with 100 mg/...

Our study pertains to evaluate the protective effect of selenium (Se), used as a nutritional supplement, against aluminium chloride induced cardiotoxicity in rats. Rats have received during 21 days either AlCl3 (400 ppm) via drinking water, AlCl3 associated with Na2SeO3 (0.5 mg/kg of diet) or only Na2SeO3. Co-administration of Se to AlCl3 treated rats alleviated heart oxidative stress objectifi...

BACKGROUND Metals can cause male infertility through affection of spermatogenesis and sperm quality. Strong evidences confirm that male infertility in metal-exposed humans is mediated via various mechanisms such as production of reactive oxygen species (ROS). Flavonoids have antioxidant and metal chelating properties which make them suitable candidates for neutralizing adverse effects of metals...

BACKGROUND AND AIMS Hemodynamic normality is crucial to maintaining the integrity of cerebral vessels and, therefore, preserving the cognitive functions of Alzheimer's disease patients. This study investigates the implications of the hemodynamic changes and the neuropathological diversifications of AlCl3-induced AD. METHODS The experimental animals were 8- to 12-wk-old male Wistar rats. The r...

In this study, a novel approach to metakaolin dealumination to produce aluminum chloride from Egyptian kaolin has been described and the prepared aluminum chloride can be used to produce polyaluminum chlorides (PACs) with various basicities (B = OH/Al values). The prepared PACs which contain Al13 ([AlO4Al12(OH)24(H2O)12] 7+ ) was investigated using XRD and colorimetric method . In XRD spectra, ...

The present study aimed to investigate the effects of intestinal endotoxemia (IETM) in a rat model of aluminum neurotoxicity established by D-galactose and aluminum trichloride (AlCl3). Adult Wistar rats were administered D‑galactose and AlCl3 to create the aluminum neurotoxicity model. The learning and memory abilities of the rats were subsequently observed using a Morris water maze test and t...