BACKGROUND 5-Fluoro-2'-deoxyuridine (5-FdU), a drug against gastric cancer, was covalently linked via its nucleobase with the amino-bisphosphonate alendronate (Ale), resulting in a new antimetabolite-bisphosphonate conjugate (5-FdU-Ale), designed for bone-targeting. MATERIALS AND METHODS The cytostatic effect of 5-FdU-Ale was evaluated in vitro compared to monomers and mixtures using CASY Tec...

We consider an arbitrary-Lagrangian-Eulerian evolving surface finite element method for the numerical approximation of advection and diffusion of a conserved scalar quantity on a moving surface. We describe the method, prove optimal order error bounds and present numerical simulations that agree with the theoretical results.

Objective. Artichoke (Cynara scolymus L.) was one of the plant remedies for primary health care. The present study was focused on the determination of chemical composition, antioxidant activities, and anti-inflammatory activity and on analyzing its major bioactive polyphenols by HPLC. Methods. Artichoke Leaves Extracts (ALE) were analyzed for proximate analysis and phytochemical and antioxidant...

Bone regeneration by systemic transplantation of mesenchymal stem cells (MSCs) is problematic due to the inability to control the MSCs' commitment, growth, and differentiation into functional osteoblasts on the bone surface. Our research group has developed a method to direct the MSCs to the bone surface by conjugating a synthetic peptidomimetic ligand (LLP2A) that has high affinity for activat...

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This paper develops a new approach to the adaptive line enhancement (ALE) of the emergency locator transmitter (ELT) signal where the input signal to the ALE is replaced by its autocorrelation function. This approach is related to the signal processing using Higher Order Statistics (HOS) of the signal recently introduced. The paper also compares the results of using the new approach with other ...

In this paper, an arbitrary Lagrangian Eulerian (ALE) based numerical method has been presented for the numerical simulation of gas-particle two phase flow with moving boundaries. The main stages for the implementation of the algorithm have been discussed. The numerical results of cylindrical implosion and 2D dusty gas explosion have shown the effectiveness of the method.

We propose a numerical scheme to compute the motion of a two-dimensional rigid body in a viscous fluid. Our method combines the method of characteristics with a finite element approximation to solve an ALE formulation of the problem. We derive error estimates implying the convergence of the scheme. 1991 Mathematics Subject Classification. 35Q30, 65M12, 76D05, 76M10.

In this article we introduce the Arcade Learning Environment (ALE): both a challenge problem and a platform and methodology for evaluating the development of general, domain-independent AI technology. ALE provides an interface to hundreds of Atari 2600 game environments, each one different, interesting, and designed to be a challenge for human players. ALE presents significant research challeng...