N -myristoyltransferase (NMT) has been an emerging target for the design of novel antifungal agents with new mode of action. A series of furan and imidazole containing heterocyclic derivatives have been designed using rational drug designing approach as NMT inhibitors. Newly Designed compounds were synthesized, characterized and evaluated for their antifungal activity against NMT. Synthesized c...

A convenient, simple and green process for the synthesis of 2,4,5-triaryl-1H-imidazole and 1,2,4,5-tetraaryl-1H-imidazole derivatives using snail shell, which is abundant in Morocco, as a catalyst in ethanol at 40 °C has been developed. Additionally, short reaction times, excellent yields, simple procedure and relative non-toxicity of the catalyst are other noteworthy advantages and make this m...

A convenient, simple and green process for the synthesis of 2,4,5-triaryl-1H-imidazole and 1,2,4,5-tetraaryl-1H-imidazole derivatives using snail shell, which is abundant in Morocco, as a catalyst in ethanol at 40 °C has been developed. Additionally, short reaction times, excellent yields, simple procedure and relative non-toxicity of the catalyst are other noteworthy advantages and make this m...

BACKGROUND AND OBJECTIVES Bacterial resistance to antibiotics has motivated the researchers to evaluate the novel anti-bacterial compounds such as some thiazole and imidazole derivatives. Thereby, in this work, we investigated the anti-bacterial effects of one new thiazole and two new imidazole derivatives on Bacillus cereus, Listeria monocytogenes, Escherichia coli, Salmonella typhimurium, Pro...

The present research describes the synthesis of novel 5-benzoyl-N-substituted-amino- and 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones 5a-c and 6a-c via the reaction of 2-benzoyl-3,3-bis(alkylthio)acrylonitriles 2a-c with N-cyanoacetohydrazide 3 and cyanoaceto-N-phenylsulfonylhydrazide 4, respectively. Also, the reactivity of the compounds 5a-c toward hydrazine hydrate to give product 1...

Abstract Amino acid decorated imidazole, pyrimidine and purine derivatives, resembling analogues of peptide nucleic acid's building blocks, have been synthesized by a three‐way multicomponent chemistry diaminomaleonitrile, one the most studied chemical precursors in prebiotic chemistry. The regioselectivity reaction between trimethyl orthoacetate selected panel α‐amino acids, was controlled ene...

A series of N-substituted imidazole derivatives was synthesized. Imidazole nucleus was reacted with ethylchloroacetate to form imidazole ester. Reaction of the imidazole ester (I) with different amines yields the desired products (1a- 1e). The compounds were characterized by FT-IR, (1)H-NMR and mass spectra. The synthesized compounds were evaluated for the antimicrobial activity against Staphyl...

Over the past two decades a significant increase in fungal infections has been observed (1). More than any other antifungal class, the azoles have been steadily refined and improved upon over the course of almost 50 years. These antifungal compounds are chemically either an imidazole or a triazole group joined to carbon atom as their functional pharmacophore and working through blocking the act...