BACKGROUND The prevalence of sensitization and allergic disease has increased significantly worldwide. The aim of the "Aalst Allergy Study" was to document prevalences of sensitization and allergic symptoms, and to evaluate the effect of personal and environmental influences on these prevalences in an unbiased Belgian pediatric population. METHODS A cross-sectional study was performed in an u...

Allergic rhinitis has been shown to affect 3% to 19% of subjects in various epidemiologic studies of different populations. Eighty percent of those with allergic rhinitis experience symptoms by the age of 20 years, and 40% have symptoms by the age of 6 years. Allergic rhinitis is a substantial burden on both adult and pediatric patients, not only because of the bothersome physical symptoms but ...

Anticholinergic agent, ipratropium bromide (IB) ameliorates symptoms of allergic rhinitis (AR) using neuroimmunologic mechanisms. However, the underlying molecular mechanism remains largely unclear. In the present study, 27 mice with AR induced by ovalbumin were randomly allocated to one of three groups: Model group, model group with IB treatment for 2 weeks, and model group with IB treatment f...

BACKGROUND Birch pollen allergic patients frequently experience gastrointestinal upset accompanied by a local allergic inflammation in the small intestine especially during the pollen season. However, it is not known if the GI pathology is connected to the subjective symptoms of the patient. The objective of this study was to evaluate the immune pathology of the duodenal mucosa and the serum Ig...

Ocular symptoms often accompany allergic rhinitis and can be as or even more bothersome for the patient than the actual nasal symptoms. Ocular manifestations of allergic rhinoconjunctivitis may result from both direct allergen-mediated mast cell stimulation on the surface of the eye and naso-ocular reflexes--histamine being one of the mediators of symptoms onset. An H1 antihistamine would be th...

Background: Snoring is a common symptom of underlying conditions, such as allergic rhinitis, Aden tonsillar hypertrophy, or obstructive sleep apnea. It important to take it into account and examine the situation prevent development severe OSA its related co-morbidities. Intranasal steroids aid in lowering airway inflammation, which lowers upper resistance while you sleep. Early steroid interven...

BACKGROUND The CC-chemokine receptor-3 (CCR3) has emerged as a target molecule for pharmacological intervention in allergic inflammation. OBJECTIVE To examine whether a dual CCR3 and H1-receptor antagonist (AZD3778) affects allergic inflammation and symptoms in allergic rhinitis. METHODS Patients with seasonal allergic rhinitis were subjected to three seven days' allergen challenge series. ...