Uterine leiomyoma is the most common benign smooth muscle tumour that originates from the myometrium. Ovarian sex steroids are responsible for the growth of such tumours, though estrogen and progesterone are not the only modulators involved in the tumourigenesis and growth of leiomyomata. The activation of glucocorticoid receptor (GR) can induce the expression and activity of estrogen sulfotran...

Abstract. Susanti R, Utami NR, Yuniastuti A. 2023. Characterization of microbiota and secretory Ig-A in the domestic duck (Anas platyrhynchos)small large intestine. Biodiversitas 24: 2458-2466. The Microbiome composition could affect duck's intestines' microenvironment, which may shape microstructure's anatomy, metabolism, immune system. Therefore, this study aims to characterize intestinal mic...

Breast cancer (BC) hormonal receptors status is assessed by immunohistochemistry (IHC), a specific, sensitive, and accessible method that guide breast cancer treatment. In this study, we evaluated progesterone receptor (PR) expression in 53 BC cases using 3 anti-PgR antibodies (AB): monoclonal (SP42 and PgR636) and polyclonal ab62621. Primary BC cases (with signed informed consent) were used to...

Background: Breast cancer is considered the most common malignant disease in female population. It known as an emerging epidemy with a great burden on women's health, which can be associated poor outcomes. Some factors including histological type, immunohistochemistry (IHC), tumor grade, and size have effects breast cancer. Objectives: This study aimed at assessing of mentioned IHC type Methods...

Protein kinase A (PKA) regulatory subunit type Iα (RIα) is a major regulatory subunit that functions as an inhibitor of PKA kinase activity. We have previously demonstrated that elevated RIα expression is associated with diffuse-to-nodular transformation of hyperplasia in parathyroid glands of renal hyperparathyroidism. The aim of the current study was to determine whether or not RIα expression...

BACKGROUND Analysis of estrogen receptor (ER), progesterone receptor (PgR) and HER2 status in early breast cancer (EBC) is increasingly being conducted in core needle biopsies (CNBs) taken at diagnosis but the concordance with the excisional biopsy (EB) is poorly documented. PATIENTS AND METHODS Patients with EBC presenting to The Royal Marsden Hospital from June 2005 to September 2007 who ha...