Antimitotic natural products that bind to cellular microtubules can be used as anticancer agents, and we are studying the cellular mechanisms of these compounds.1 The fungal metabolite phomopsin A is a key structure in these studies, and we are currently pursuing its synthesis.2 Our retrosynthetic analysis of phomopsin A targeted the chiral tertiary alkyl-aryl ether as a key disconnection withi...

In this study, methoxylated flavonoids and volatile constitutions of Agrostis gigantea Roth (Poaceae) were investigated for the first time. The flavonoids were identified by spectroscopic methods (1H-NMR, 13C-NMR, COSY, NOSEY, TCOSY, and HMBC). The volatile constitutions of aerial parts and seeds were analyzed by gas chromatography–mass spectrometry (GC-MS). Two methoxylated flavonoids, luteoli...

Title of Dissertation: DEVELOPMENT OF ARYL SILOXANE CROSSCOUPLING TECHNOLOGY AND ITS APPLICATION TO THE SYNTHESIS OF COLCHICINE AND ALLOCOLCHICINE DERIVATIVES William Michael Seganish, Doctor of Philosophy, 2005 Dissertation directed by: Professor Philip DeShong Department of Chemistry and Biochemistry One of the most versatile methods for the formation of aryl-aryl bonds is the palladium-catal...

High energy density, high temperature, and low loss dielectric polymers have drawn increasing attention in research owing to their potential applications power electronic pulsed devices. In this study, a new class of organo-soluble dipolar glass (DGPs) are synthesized via polycondensation post-functionalization poly(aryl ether)s (PAEs) based on phenolphthalin. Due the nonplanar backbone structu...

Total syntheses of yatakemycin, PDE-II, dictyodendrins, and heptaphylline are described. This article focuses on the formation of aryl carbon-nitrogen bonds by two methods: first by an aromatic amination reaction using a combination of CuI and CsOAc, and then by a benzyne-mediated one-pot cyclization-functionalization sequence. The aryl amination reaction shows a high functional group compatibi...

Morphine and related narcotic agonists produce mixed depressant and/or stimulant effects in a wide variety of animals including man (1,2) . These effects are not only species but also time and dose related . It is not gener ally appreciated that even a single dose of morphine in a given species, such as the rat, may have initial depressant and subsequent stimulant effects. We believe this is an...