In the practice of pediatric cardiology, situations are possible when a child with congenital heart disease cannot be subjected to radical or even hemodynamic surgery. As rule, such severe defects combined other genetic anomalies, which ultimately lead palliative status newborn. This situa­tion is serious ethical and psychological challenge for medical workers in both antenatal postnatal period...

Evaluation of the fetal heart at 11-13 + 6 weeks of gestation is indicated for women with a family history of congenital heart defects (CHD), a previous child with CDH, or an ultrasound finding associated with cardiac anomalies. The accuracy for early detection of CHD is highly related to the experience of the operator. The 4-chamber view and outflow tracts are the most important planes for ide...

Success of surgical repair of congenital heart defects in the past five decades has enabled survival into adulthood. Women born with congenital heart diseases reach child-bearing age with or without surgical repair of those lesions. Specifically, atrial septal defect (ASD) is a non-lethal, acyanotic lesion in which survival into adulthood with or without surgery is common place. Types of ASD an...

catheter ablation is an accepted, highly effective modality of treatment for cardiac arrhythmias in children. the success rate depends on the operator’s experience, especially in cases involving complex anatomies. we hereby report our recent experience of successful ablation of accessory pathways in three children with complex congenital heart diseases. the first case was a 7-year-old girl with...

cor triatriatum   sinistrum is a rare congenital cardiac malformation, accounting for about 0.1-0.4% of all congenital heart diseases and characterized by the presence of a fibromuscular membrane that subdivides the left atrium into two chambers in the classical form. while classic cor triatriatum in most patients can be observed during the neonatal period or early infancy, it is very rare in a...

a 29-year-old woman was referred to our hospital due to exacerbation in dyspnea on exertion and easy fatigability. a known case of congenitally corrected transposition of the great vessels and congenital complete heart block, she had already received a permanent single-chamber pacemaker. decision was made to implant a biventricular pacemaker for the treatment of the failing heart. excellent cor...

Exercise; heart failure; coronary artery disease; interleukins. Anti-inflammatory Effect of Physical Training in Heart Failure: Role of TNF-α and IL-10 Miguel Luiz Batista Júnior1, Renato Delascio Lopes2,3, Marília Cerqueira Leite Seelaender1, Antonio Carlos Lopes2 Grupo de Biologia Molecular da Célula Instituto de Ciências Biomédicas I e Departamento de Medicina Interna Universidade Federal de...

OBJECTIVES To determine whether bronchial colonisations/infections with periodontopathogenic bacteria are associated with elevated inflammatory markers such as MMPs, interleukins and Tumor necrosis factor alpha in the bronchial fluid. METHODS Periodontal status was assessed in consecutive outpatients planned for elective bronchoscopies, and PCR for periodontopathogenic bacteria was performed ...

Objective: The present article was motivated by the frustrating experiences with four patients who underwent surgical treatment of ostium secundum atrial septal defect (ASD-II) and who died in extremely dramatic circumstances. Method: This is a retrospective study based on clinical data. The bibliographical research included: paradoxical thromboembolism (cerebral, pulmonary or mesenteric), cent...

Decorin, a small multifunctional proteoglycan, is expressed by sprouting endothelial cells (ECs) during inflammation-induced angiogenesis in vivo and by human ECs co-cultured with fibroblasts in a collagen lattice. To investigate how decorin is induced, human EA.hy 926 ECs and/or human umbilical vein ECs were treated with interleukin (IL)-10 and IL-6. Both treatments induced decorin mRNA in hum...