EXAMINATIOX of the bomie issart’ow imi umitreated perniciotts aneliiia reveals that. erythmopoiesis is megaloblastic imi type.’ ‘ Either spomitaneous remission,’ or the administratiomi of liver extract,3 folic acid,4 or vitamin B125 causes a disappearamice of the characteristic miiegaioblasts amid the appearance of miormol)lastic niaturat iou . This change begi mis a few hours after specific th...

By JULIUS R. KREVANS, DUDLEY P. JACKSON, C. LOCKARD CONLEY AND ROBERT C. HARTMANN H E tIOLYTIC TRANSFUSION REACTIONS nitty be associated with the developnsemst of a serious hemorrhagic temidemicy. As early as 1919, Drimsker amid Brittinghamm reported the occurrence of umsexplained bleedimsg followimig the tramssfusioms of serologically imscompatible red blood cells, amid since thets a few’ simi...

T HE PRESENCE of alkalimse plsosphatase its segmented neutrophils has been well established. Although the origin, msature amid fumiction of this enzyme are poorly umsderstood, variations from the miornial leukocytic alkaline phosphatase activity have been demonstrated by biochensical amsd histoehemical methods. In chronic myelogemsous leukemia the emszynse is greatly deficient whereas its neutr...

and its treatment is frequently unsatisfactory, despite the introduction of intravenous iron preparations. The presence of anemia may hinder adequate physical or orthopedic treatment arid may produce a degree of lassitude that considerably aggravates the joint disability. This anemia, therefore, seemed worthy of study amid investigations of three aspects are reported here: 1. Changes in periphe...

EUKEMIA imivolves mans’ tissues and may often become complicated by imifection, bleeding, malmiutrition an(l mechanical intem-feremice with orgamis. Stud!ies have beemi made imi this laboratory on the nature of the hemorrhagic diathesis as it OC(tIPS ili leukemia. This report pertaimis chiefly to heparin-protamimic titration, to prothroml)imi activity of plasma and to platelet concentration. i)...

ZLOTXICK T HE associatiomi of hypem'globulimseniia with ams imscm'ease imi the msunsber of boise marrow plasmna cells is a well-kmsowmi phenomemion. Bing & Plum' first drew attenstioms to this amid noted that " a comparison of the various affectiomss in w'hsichi hsyperglobunlinsemssia is found, shows as a comnmon feature ais augmeustatious of the plasmusa cells amid other cells belomsginsg to t...

Using the particular example of online banking services, we examine the effects of pricing strategies on the demand for different modes of online banking given that the market exhibits network externalities. Most literature concerning the economics of networks deals with a single durable good where, in a multi-period setting, the consumer decides whether or not to purchase the good. Once the de...

The software developers have been wholeheartedly implemented the various design patterns in current years. There is sufficient confirmation that patterns can have a valuable blow on software quality, on the other hand in some situations patterns have been improperly implemented because of having not too much experience. A software developer can make the design process simpler, well design to be...

The study of virus disease emergence, whether it can be predicted and how it might be prevented, has become a major research topic in biomedicine. Here we show that efforts to predict disease emergence commonly conflate fundamentally different evolutionary and epidemiological time scales, and are likely to fail because of the enormous number of unsampled viruses that could conceivably emerge in...