BACKGROUND Therapeutic hypothermia during operation decreases postoperative intra-abdominal adhesion formation. We sought to determine the most appropriate duration of hypothermia, and whether hypothermia affects the expression of tissue plasminogen activator (tPA). METHODS 80 male BALB/c mice weighing 25-30 g are randomized into one of five groups: adhesion model with infusion of 15°C saline...

Chorioamnionitis is caused by intrauterine infection with microorganisms including Candida albicans (C.albicans). Chorioamnionitis is associated with postnatal intestinal pathologies including necrotizing enterocolitis. The underlying mechanisms by which intra-amniotic C.albicans infection adversely affects the fetal gut remain unknown. Therefore, we assessed whether intra-amniotic C.albicans i...

OBJECTIVES/HYPOTHESIS Otoacoustic emissions have frequently been used for newborn hearing screening. However, they have low specificities and high referral rates. The presence of amniotic fluid in the middle ear is one reason for these problems. The aim of this study was to determine the effects of human amniotic fluid on otoacoustic emissions and on middle-ear function. METHODS Forty-six chi...

To the Editor:-The report by Scheingraber et al.’ highlights the phenomenon of acidemia after infusion of 0.9%) saline in the perioperative period. The accompanying editorial’ discusses several relevant points; however, we are disappointed that neither the article nor the editorial addresses the central issue of the relative merits of the Stewart approachg in describing acidbase physiology and ...

INTRODUCTION Exposure to prenatal inflammation is associated with diverse adverse neurobehavioral outcomes in exposed offspring. The mechanism by which inflammation negatively impacts the developing brain is poorly understood. Metabolomic profiling provides an opportunity to identify specific metabolites, and novel pathways, which may reveal mechanisms by which exposure to intrauterine inflamma...

We recently showed that a fixed volume (i.e., 40 ml) of saline infused into the venous circulation of an arterially occluded vascular bed increases muscle sympathetic nerve activity (MSNA) and blood pressure. In the present report, we hypothesized that the volume and rate of infusion would influence the magnitude of the sympathetic response. Blood pressure, heart rate, and MSNA were assessed in...

Objective: To assess the effects of intravenous vitamin C administration on the vasomotor responses to intracoronary L-arginine infusion in epicardial coronary arteries. Methods: 28 patients with coronary artery disease and stable angina were enrolled in the study. Eight patients received intracoronary infusions of 150 mmol/min L-arginine before and after intravenous infusion of vitamin C, 10 p...

introduction: the administration of crystalloid fluids is considered as the first line treatment in management of trauma patients. infusion of intravenous fluids leads to various changes in hemodynamic, metabolic and coagulation profiles of these patients. the present study attempted to survey some of these changes in patients with mild severity trauma following normal saline infusion. methods:...