نتایج جستجو برای: amorph urate
تعداد نتایج: 4153 فیلتر نتایج به سال:
BERGER,LAWRENCE,T'SAIFANY~~ANDALEXANDER B. GUTMAN. Efect of drugs that alter uric acid excretion in man on uric acid clearance in the chicken. Am. J. Physiol. rg8(3) : 575-580. 1960. -In 43 chickens, the mean Cinulin was 4.7 + I .8 ml/min. (I .8 =t 0.8 ml/kg/ min.), mean C urate 29.0 rt 14.9 ml/min. (I 1.3 =t 6.0 ml/kg/ min.) and mean Turate 1.30 zt 0.69 mg/min. (0.48 & 0.24 mg/kg/ min.). Tubul...
The transport mechanism of urate and p-aminohippurate (PAH) was evaluated in microvillus membrane vesicles isolated from the renal cortex of the mongrel dog. Imposition of a transmembrane pH gradient (pHo less than pH1) markedly accelerated the uptake of [14C]urate and [3H]PAH and caused the transient accumulation ("overshoot") of each anion above its final level of uptake. The transport of ura...
The effect of serum and synovial fluid obtained from six healthy subjects and from 12 patients with gout, six with rheumatoid arthritis and 18 with calcium pyrophosphate dihydrate arthropathy (CPPD) on the rate of in vitro urate crystal formation was measured. Gouty and normal serum produced similar results. Gouty synovial fluids promoted urate crystal formation significantly more than did rheu...
Uric acid is the product of purine metabolism and its increased levels result in hyperuricemia. A number of epidemiological reports link hyperuricemia with multiple disorders, such as kidney diseases, cardiovascular diseases and diabetes. Recent studies also showed that expression and functional changes of urate transporters are associated with hyperuricemia. Uric acid transporters are divided ...
Acute gouty arthritis occurs when crystals of monosodium urate form and deposit in joints and connective tissue. These crystals then provoke the characteristic acute inflammatory response of gout (Seegmiller, 1965), and may accumulate chronically forming gouty tophi. Although deposition of urate crystals from hyperuricaemic body fluids is an essential requirement in the pathogenesis of gout, on...
INTRODUCTION There is increasing evidence that both hyperuricemia and gout increase the risk of cardiovascular morbidity and mortality. Whether urate crystal precipitation confers a particular risk above what is already inherent in having hyperuricemia is not well established. We conducted this cohort study to establish whether the presence of monosodium urate crystal precipitation per se is as...
BACKGROUND Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have found common genetic variants of SLC2A9 to be associated with increased serum urate level and gout. The SLC2A9 gene encodes a facilitative glucos...
0886-1714/99 5.00 © 1999 Int. Union Physiol. Sci./Am.Physiol. Soc. 80 The renal urate handling in humans has been explained for many years by a “four-component model.” The purpose of this review is to reevaluate the validity of the theory behind this hypothetical model in the light of the transport mechanisms that were characterized recently in the apical membrane (brush-border membrane; BBM) o...
BACKGROUND AND PURPOSE Serum urate concentration is associated with cardiovascular disease, and hyperuricemia predicts first-ever stroke. We explored the association of admission urate level with mortality, placement, and risk of further vascular events after acute stroke. METHODS In patients with ischemic stroke or primary intracranial hemorrhage, we determined the association of urate level...
GLUT9 (SLC2A9) is a newly described urate transporter whose function, characteristics, and localization have just started to be elucidated. Some transport properties of human GLUT9 have been studied in the Xenopus laevis oocyte expression system, but the type of transport (uniport, coupled transport system, stoichiometry ... .) is still largely unknown. We used the same experimental system to c...
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