نتایج جستجو برای: amplification factor
تعداد نتایج: 895445 فیلتر نتایج به سال:
A T-->C point mutation is shown to specifically inhibit PCR amplification when compared to wild-type controls in exon H of the factor IX gene. Multiple primers of different lengths and locations were designed to examine this phenomenon. The experiments suggest that poor annealing and/or extension from the downstream primer are responsible for the observed inhibition and that the mutation can ex...
In climate change science the term 'Arctic amplification' has become synonymous with an estimation of the ratio of a change in Arctic temperatures compared with a broader reference change under the same period, usually in global temperatures. Here, it is shown that this definition of Arctic amplification comes with a suite of difficulties related to the statistical properties of the ratio estim...
Over 30% of ERα breast cancer patients develop relapses and progress to metastatic disease despite treatment with endocrine therapies. The pioneer factor PBX1 translates epigenetic cues and mediates estrogen induced ERα binding. Here we demonstrate that PBX1 plays a central role in regulating the ERα transcriptional response to epidermal growth factor (EGF) signaling. PBX1 regulates a subset of...
AIM To investigate the clinicopathological features and prognostic implications of combined MYC and fibroblast growth factor receptor 1 (FGFR1) status in esophageal squamous cell carcinomas (ESCCs). METHODS All patients with ESCC (n = 180) underwent surgical resection at Seoul National University Hospital sometime between 2000 and 2013. A tissue microarray was constructed using cores obtained...
BACKGROUND Previous studies have shown that human epidermal growth factor receptor 2 (HER2) may play an important role in the invasion and metastasis of pancreatic cancer, but the relationship between HER2 amplification level and prognosis of pancreatic cancer patients is still controversial. Therefore, we performed a meta-analysis to determine the prognostic significance of HER2 amplification ...
We report efficient amplification of weak femtosecond supercontinuum pulses by a stimulated Raman scattering process in pressurized H(2) gas excited with 350-fs-duration frequency-doubled pulses from a regenerativeamplified Ti:sapphire laser. An amplification factor of 10(9) is obtained at the wavelength of 465 nm for seed pulses produced by supercontinuum generation in glass.
We report measurement of efficient amplification of weak femtosecond supercontinuum seed pulses by use of a noncollinear optical parametric process in BBO crystal pumped with 150-fs pulses from a frequency-doubled regenerative-amplified Ti:sapphire laser at 390nm . The highest amplification factor, 10(8) , was achieved for 3x10(-16)J energy seed pulses at wavelength of 560nm.
The influence of increased train loads on the dynamic amplification for bridge action effects are investigated using simple models such as two-mass oscillators. The results show, the bridge dynamic amplification factor decreases when carriage weights are increased. This procedure facilitates more accurate calculation of fatigue stresses.
Human epidermal growth factor receptor 2 (HER2 or ErbB2) can be overexpressed, amplified and/or mutated in malignant tumors, and is a candidate for therapeutic targeting. However, molecular associations and clinical significances of these alterations were controversial in lung cancer. In this study, we investigated the frequency and clinicopathological significance of HER2 dysregulation in pati...
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