Using mouse gene expression microarray analysis, we obtained dynamic expression profiles of the whole genome in a depilation-induced hair growth mouse model. S100A3 expression increased during the anagen phase and returned to normal during the telogen phase. The effects of S100A3 blockade on the hair growth cycle were examined in mice after subcutaneous injection of an anti-mouse S100A3 antibod...

CME EDUCATIONAL OBJECTIVES: 1.Identify the clinical features of loose anagen syndrome.2.Distinguish between loose anagen syndrome and other types of alopecia in a young child.3.Understand the natural history of loose anagen syndrome. A healthy 3-year-old white girl presented to the pediatric dermatology clinic for evaluation of thin hair. She was born with little hair and slowly grew thin blond...

In most mammals, each hair follicle undergoes a cyclic process of growing, regressing and resting phases (anagen, catagen, telogen, respectively) called the hair cycle. Various biological factors have been reported to regulate or to synchronize with the hair cycle. Some factors involved in the extracellular matrix, which is a major component of skin tissue, are also thought to regulate the hair...

Binding for testosterone, 5a!-dihydrotestosterone, estradiol-17P, and progesterone by the 105,000 x g supernatant fraction of homogenates of rat skin was demonstrated by equilibrium dialysis. The binding ability was pH-dependent (maximum binding for 5oc-dihydrotestosterone at pH 7.5) and was destroyed after heating at 60” for 5 min. The content of soluble proteins in rat skin was found to incre...

BACKGROUND Fluridil, a novel topical antiandrogen, suppresses the human androgen receptor. While highly hydrophobic and hydrolytically degradable, it is systemically nonresorbable. In animals, fluridil demonstrated high local and general tolerance. OBJECTIVE To evaluate the safety and efficacy of a topical anti- androgen, fluridil, in male androgenetic alopecia. METHODS In 20 men, for 21 da...

Hair follicles form in prenatal skin and mature in the postnatal period, establishing a growth cycle in 3 phases: telogen (resting), anagen (growth), and catagen (regression). Based on the knowledge that Sonic hedgehog (Shh) expression is necessary for the embryonic development of hair follicles, and that anagen in the postnatal cycling follicle has morphologic similarities to the epithelial in...

The expression of a cell proliferation-associated human nuclear antigen was immunohistochemically studied in human anagen hair and hair follicles using the monoclonal antibody Ki-67. The reaction of Ki-67 in mature anagen hair follicles was observed in the hair matrix cells and outer root sheath (ORS) cells. Nuclear staining was seen in a small number of matrix cells and in some ORS cells; this...