Introduction To understand the intricate pathways that regulate biological processes at the cellular level, we need to be able to capture data about the subcellular distributions of proteins and how these vary within cell populations. Automated analysis of fluorescence microscope images provides a powerful way of acquiring such information. The high specificity of fluorescent probes for labelin...

We contribute improvements to a Lagrangian dual solution approach applied to large-scale optimization problems whose objective functions are convex, continuously differentiable and possibly nonlinear, while the nonrelaxed constraint set is compact but not necessarily convex. Such problems arise, for example, in the split-variable deterministic reformulation of stochastic mixed-integer optimizat...

Invasive species cause large economic impacts, have complex environmental impacts (Pimentel 2011) and are now considered to be among the four major threats to biodiversity. This has been recognised by their inclusion in the Strategic Plan for Biodiversity of the Convention on Biological Diversity (Aichi Target 9; UNEP 2011). Combating invasions clearly requires a prioritisation approach, taking...

Abstract Date Presented 04/02/2022 For people experiencing homelessness (PEH), cognition may be assessed as a predictor of independent living skills and housing stability, but it does not include performance-based assessment. A scoping review was completed to identify what methods have been used evaluate functional PEH increase knowledge current practices support the role OT in supporting trans...

INTRODUCTION This study was conducted in the Boland health district of the Cape Winelands of South Africa where there is a high tuberculosis incidence and prevalence. A survey conducted on 211 farms in the study district during 1998, reported that 65% (n = 9042) of all workers on these farms, were temporarily employed. Temporary farm workers live in communities either within or the outskirts of...

EXPERIENCE of the limitations of cortisone and hydrocortisone as therapeutic agents in the management of patients with rheumatoid arthritis has led to a search for newer and more potent compounds with fewer undesirable side effects. With the knowledge that the physiological properties of the adrenal steroids can be modified by relatively minor adjustments of their structural formula, a number o...

James Slater, MD, FACC,* Robert J. Brown, MD,* Tracy A. Antonelli, MPH,† Venu Menon, MD, FACC,* Jean Boland, MD,‡ Jacques Col, MD,§ Vladimir Dzavik, MD,\ Mark Greenberg, MD, FACC,¶ Mark Menegus, MD, FACC,¶ Cliff Connery, MD,* Judith S. Hochman, MD, FACC,* for the SHOCK Investigators New York, New York; Watertown, Massachusetts; Liège, Belgium; Brussels, Belgium; Edmonton, Alberta, Canada; Bronx...