BACKGROUND Duarte galactosemia (DG) is frequently detected in newborn-screening programs. DG patients do not manifest the symptoms of classic galactosemia, but whether they require dietary galactose restriction is controversial. We sought to assess the relationships of selected galactose metabolites (plasma galactose, plasma galactitol, erythrocyte (RBC) galactitol, RBC galactonate, and urine g...

The syndrome of disseminated intravascular coagulation (DIC) 1 is a recognized complication of acute hemolytic episodes in both man (1-3) and laboratory animals (4, 5) and has been induced experimentally in monkeys and dogs by infusion of autologous red blood cell stroma (6, 7). The mechanism of stromainduced D I C may be analogous to the demonstrable procoagulant activity of red cell membrane ...

We present results for the leading hadronic contribution to the muon anomalous magnetic moment due to strange quark-connected vacuum polarisation effects. Simulations were performed using RBC–UKQCD’s Nf = 2 + 1 domain wall fermion ensembles with physical light sea quark masses at two lattice spacings. We consider a large number of analysis scenarios in order to obtain solid estimates for residu...

The vasoocclusive process in patients with sickle cell disease (SCD) is complex and involves interactions among sickle erythrocytes (SS-RBC), vascular endothelium, and plasma and cellular components. The role of neutrophils (PMN) in vasoocclusion has not been examined. Patients with SCD appear to have chronically activated PMN. Because the first step in PMN activation is particle recognition, w...

During cell entry, reovirus particles with a diameter of 70-80 nm must penetrate the cellular membrane to access the cytoplasm. The mechanism of penetration, without benefit of membrane fusion, is not well characterized for any such nonenveloped animal virus. Lysis of RBCs is an in vitro assay for the membrane perforation activity of reovirus; however, the mechanism of lysis has been unknown. I...

During capillary transit, red blood cells (RBCs) must exchange large quantities of CO2 and O2 in typically less than one second, but the degree to which this is rate-limited by diffusion through cytoplasm is not known. Gas diffusivity is intuitively assumed to be fast and this would imply that the intracellular path-length, defined by RBC shape, is not a factor that could meaningfully compromis...

Purpose. The incidence of liver tumors is rising in USA. The purpose of this study was to evaluate liver oxido-reductive status in the presence of chronic liver disease and hepatocellular carcinoma (HCC). Methods. Glutathione species and ophthalmate (OA) concentrations were measured by LC-MS in processed plasma and red blood cells (RBC) from infected Woodchuck with hepatitis virus (WHV). Blood ...

1.5 Range of Application, Dosage, Mode of Administration 1.5.1 Indications 1.5.1.1 General Principles 1.5.1.2 Acute Blood Loss 1.5.1.3 Chronic Anemias 1.5.2 Indications for Special RBC Concentrates 1.5.2.1 Irradiated Leukocyte-Depleted RBC Concentrates 1.5.2.2 Washed RBC Concentrates 1.5.2.3 Cryopreserved RBC Concentrates 1.5.2.4 CMV and Parvovirus B19 1.5.3 Selection and Dosage of RBC Concentr...

1.5 Range of Application, Dosage, Mode of Administration 1.5.1 Indications 1.5.1.1 General Principles 1.5.1.2 Acute Blood Loss 1.5.1.3 Chronic Anemias 1.5.2 Indications for Special RBC Concentrates 1.5.2.1 Irradiated Leukocyte-Depleted RBC Concentrates 1.5.2.2 Washed RBC Concentrates 1.5.2.3 Cryopreserved RBC Concentrates 1.5.2.4 CMV and Parvovirus B19 1.5.3 Selection and Dosage of RBC Concentr...

Micropore filtration of dilute red blood cell (RBC) suspensions is a widely known method for determining red blood cell deformability. Use of this method for cells from various laboratory animal species does require considering the effects of the cell size to pore size ratio and of suspension hematocrit. In general, previous animal studies have utilized 5% hematocrit suspensions and five micron...