نتایج جستجو برای: animal testing alternatives
تعداد نتایج: 580515 فیلتر نتایج به سال:
The Center strives to develop new non-whole-animal test methodologies based on understanding mechanisms of toxicity of chemicals, consumer products, and drugs for the evaluation of safety. The Center will strive for scientific excellence, and to provide superior methods which will replace existing strategies.
OBJECTIVE To evaluate the clinical impact of nationwide implementation of genome-wide non-invasive prenatal testing (NIPT) in pregnancies at increased risk for fetal trisomies 21, 18 and 13 (TRIDENT study). METHOD Women with elevated risk based on first trimester combined testing (FCT ≥ 1:200) or medical history, not advanced maternal age alone, were offered NIPT as contingent screening test,...
Altex 31, 2/14 224 Alternatives Initiative in Sri Lanka: Preand Post-Conference Workshops at the Inaugural Scientific Conference of the Sri Lanka Association for Laboratory Animal Science Mangala Gunatilake 1, Francois Busquet 2, and Mohammad A. Akbarsha 3 Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka; Center for Alternatives to Animal Testing (CAAT)-Europe, Ko...
This study compared the accuracy of several models for obtaining genetic evaluations of calving difficulty. The models were univariate threshold animal (TAM), threshold sire-maternal grandsire (TSM), linear animal (LAM), and linear sire-maternal grandsire (LSM) models and bivariate threshold-linear animal (TLAM), threshold-linear sire-maternal grandsire (TLSM), linear-linear animal (LLAM), and ...
Acute systemic toxicity testing provides the basis for hazard labeling and risk management of chemicals. A number of international efforts have been directed at identifying non-animal alternatives for in vivo acute systemic toxicity tests. A September 2015 workshop, Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing, reviewed the state-of-...
BACKGROUND There is great need for the development of highly accurate cost effective technologies that could facilitate the widespread adoption of noninvasive prenatal testing (NIPT). METHODS We developed an assay based on the targeted analysis of cell-free DNA for the detection of fetal aneuploidies of chromosomes 21, 18, and 13. This method enabled the capture and analysis of selected genom...
Noninvasive prenatal testing (NIPT) validation studies show high sensitivity and specificity for detection of trisomies 13, 18, and 21. False negative cases have rarely been reported. We describe a false negative case of trisomy 13 and another of trisomy 18 in which NIPT was commercially marketed directly to the clinician. Both cases came to our attention because a fetal anatomy scan at 20 week...
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