Polymeric ion-exchange membranes have come a long way since their invention, benefiting wide range of processes, ranging from desalination to fuel cells. However, challenges such as alkaline stability, monovalent ion selectivity, cost-effectivity, and process sustainability largely persist. This work showcases stable anion-exchange made by hot-pressing polyelectrolyte complex poly(styrenesulfon...

Flowthrough anion exchange chromatography is commonly used as a polishing step in downstream processing of monoclonal antibodies and other therapeutic proteins to remove process-related impurities and contaminants such as host cell DNA, host cell proteins, endotoxin, and viruses. DNA with a wide range of molecular weight distributions derived from Chinese Hamster Ovary cells was used to advance...

The effective ion-exchange capacities of ion-exchange materials were determined by measuring the change in the equilibrium conductivity of a column packed with analyte. The developed instrumental method can provide effective ion-exchange capacities for both cation and anion exchangers with simple operations. The cation-exchange capacity of a weak-acid cation-exchange resin (TSKgel SuperIC-Catio...