Meysam Yarie was born in 1987 in Malayer/ Hamedan, Iran. He received his B.Sc. in Applied Chemistry (2010) from Malek-Ashtar University of Technology and M.Sc. in Organic Chemistry (2012) from Kurdistan University under the supervision of Dr. Kamal Amani. He is currently working towards his Ph.D. under the supervision of Professor Mohammad Ali Zolfigol. His research interest is the synthesis, c...

The first total synthesis of dinemasone A, a bioactive metabolite with a spiroketal moiety, is described. The main strategy for the construction of the spiroketal unit involves a double intramolecular hetero-Michael addition (DIHMA) of an ynone moiety. The thus obtained axial-equatorial mono anomeric spiroketal, on spiroepimerization with ZnBr(2), was converted into the requisite axial-axial do...

In tumoral cells derived from the insulin-producing rat cell line RINm5F, both low- and high-Km glucose-phosphorylating enzymic activities were present. The hexokinase-like enzyme was inhibited by glucose 6-phosphate and displayed a greater affinity for but lower maximal velocity with alpha-D-glucose than beta-D-glucose. A comparable anomeric behavior of hexokinase was observed in breast cancer...

In this note, an hydrozirconation/bromination/Michaelis-Arbuzov sequence was developped to introduce a trimethylene phosphonate unit on ketopyranosides. Performed polyfunctional substrates bearing orthogonal protecting groups, new approach provided straightforward entry towards large diversity of glycophosphomimetics having quaternary anomeric position.

For the first time in natural O-glycosides, a large amount of non-exo-anomeric conformation is experimentally detected, in solution.

meysam yarie was born in 1987 in malayer/ hamedan, iran. he received his b.sc. in applied chemistry (2010) from malek-ashtar university of technology and m.sc. in organic chemistry (2012) from kurdistan university under the supervision of dr. kamal amani. he is currently working towards his ph.d. under the supervision of professor mohammad ali zolfigol. his research interest is the synthesis, c...

This study introduces new methods of screening for and tuning chiral space and in so doing identifies a promising set of chiral ligands for asymmetric synthesis. The carbafructopyranosyl-1,2-diamine(s) and salens constructed therefrom are particularly compelling. It is shown that by removing the native anomeric effect in this ligand family, one can tune chiral ligand shape and improve chiral bi...