bakcground: the aim of itp treatment is to prevent intracranial hemorrhage and increase the platelet count rapidly. this study was conducted with the objective of comparing the efficacy of anti-d immunoglobulin (ig) with dexamethasone in treating childhood itp. materials and methods: in this randomized prospective control trial, 20 itp patients (platelet count< 20,000/µl) younger than 16 were s...

IgG autoantibodies eluted from RBCs of antiglobulin positive normal blood donors contained at least two antibody populations, an IgG autoantibody (Ab 1), and an IgG population (Ab 2) that agglutinated RBCs coated with some Rh(D) alloantibodies. Eight of 24 autoantibody eluates tested agglutinated 3 of 10 anti-Rh(D) sensitized RBCs. The agglutinating activity was inhibited specifically by preinc...

A collaborative study involving nine independent assays by eight laboratories has recalibrated the anti-D concentration of the International Reference Preparation of Anti-D Immunoglobulin (68/417) in terms of the International Standard for Anti-Rho (anti-D) Incomplete Blood Typing Serum (64/16). This study was carried out when it was found that 68/419 had been calibrated not against 64/16, as o...

Transplacental or fetomaternal hemorrhage (FMH) may occur during pregnancy or at delivery and lead to immunization to the D antigen if the mother is Rh-negative and the baby is Rh-positive. This can result in hemolytic disease of the fetus and newborn (HDFN) in subsequent D-positive pregnancies. The aim of this study is to highlight the challenges associated with the effective management and pr...

Prior to the availability of anti-D immunoglobulin (anti-D Ig), the incidence of Rh(D) alloimmunisation in D negative women following two deliveries of D positive, ABO-compatible infants was approximately 16%, and haemolytic disease of the newborn (HDN) due to anti-D was a significant cause of morbidity and mortality. Following routine post-partum administration of anti-D Ig, the rate of alloim...

Incidence of immune hydrops fetal is decreasing with the liberal use of anti-D immunoglobulin, But this condition has not been eradicated. We report here a case of immune hydrops fetalis detected on ultrasonography.

Background: Rh D antigen is the next most important after ABO antigens in the field of transfusion medicine. Weak D refers to reduced expression of D antigen on the red blood cell that requires an extended testing with indirect antiglobulin test (IAT) to get detected. Clinical importance of weak D arises when labelling the donor and patient, as the donor is labelled as D positive, patient as D ...