Selenium administration resulted in a marked decrease in the activity levels of the liver succinate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase while pyruvate dehydrogenase increased significantly (P<0.001) in the wistar rat. The degree of decrease of these enzymes was significantly less (P<0.001) when rats were treated with curcumin, a natural constituent Curcuma longa. Curc...

OBJECTIVES This study aimed to estimate the effects of 4-nonylphenol (NP), a ubiquitously present surfactant in aquatic environments, on the anti-oxidant systems of the liver in the Far Eastern catfish Silurus asotus. METHODS Changes in biochemical parameters involved in glutathione (GSH)-related and other anti-oxidant systems were analyzed following 4 weeks of 4-NP administration (0.1 and 1....

Ribonucleotide reductase small subunit B (RRM2B) is a stress response protein that protects normal human fibroblasts from oxidative stress. However, the underlying mechanism that governs this function is not entirely understood. To identify factors that interact with RRM2B and mediate anti-oxidation function, large-scale purification of human Flag-tagged RRM2B complexes was performed. Pyrroline...

Probiotics could effectively eliminate excess ROS generated during aging or lipid metabolism disorders, but their mechanism is unclear. The major purpose of this study was to investigate the L. plantarun AR113 alleviating oxidative stress injury in D-galactose induced mice. result showed that pretreatment with significantly relieving H2O2 cytotoxicity HepG2 c...

Parkinson`s disease (PD) is the second most common neurodegenerative disorder after Alzheimer`s disease. It is a chronic and progressive disease, and mostly afflicts elderlies. PD starts with sudden onsets and the exact cause of the disease is still unknown, however there are some early symptoms that can help us to diagnose the disease and ameliorate its effects. PD is a multi-factorial disease...

Objectives: To ascertain the protective effect of p53 tumor protein by monitoring its levels in comparison with antioxidant enzymes, against any type cancer that can be caused chronic exposure traffic policemen to air pollutants.&#x0D; Methods: This study comprises 140 participants, who have been divided into two groups (Traffic police and Office police). PAHs were analyzed for each participant...

In traditional medicine, Jasonia glutinosa (L.) DC or rock tea (RT) has been mainly used to treat digestive and respiratory pathologies but also as an antimicrobial antidepressant herbal remedy. An ethanolic extract of RT demonstrated have antioxidant anti-inflammatory effects, which may be explained by its phytochemical profile, rich in polyphenols pigments. The aim this study is investigate t...

Entamoeba histolytica, a microaerophilic enteric protozoan parasite, causes amebic colitis and extra intestinal abscesses in millions of inhabitants of endemic areas. Trophozoites of E. histolytica are exposed to a variety of reactive oxygen and nitrogen species during infection. Since E. histolytica lacks key components of canonical eukaryotic anti-oxidative defense systems, such as catalase a...

Cryptococcus neoformans is an opportunistic pulmonary fungal pathogen that disseminates to the CNS causing fatal meningitis in immunocompromised patients. Dendritic cells (DCs) phagocytose C. neoformans following inhalation. Following uptake, cryptococci translocate to the DC lysosomal compartment and are killed by oxidative and non-oxidative mechanisms. DC lysosomal extracts kill cryptococci i...

Ferulic acid, a phenolic acid derived mainly from a Chinese herb Angelica Sinensis Radix (ASR), was reported to reduce the formation of free radicals. Danggui Buxue Tang (DBT), a herbal decoction composing of Astragali Radix (AR) and ASR, has been utilized for more than 800 years in China having known anti-oxidative property. Ferulic acid is a major active ingredient in DBT; however, the role o...