Micrococcus luteus was employed for the assay of rifampicin in fixed-dose combinations (FDCs) of anti-tubercular drugs containing rifampicin, isoniazid, pyrazinamide and ethambutal. The microbiological assay was compared with spectrophotometric assay for estimation of rifampicin in the FDCs as well as in dissolution studies of the FDCs. The microbiological method was found to be more sensitive ...

Tubercular dactylitis or spina ventosa is the tubercular infection of phalanges, metacarpals and metatarsals termed after cystic swelling short tubular bones by infection. Here we presented two rare cases in a 10 years old female 16 male patients. In both there was digits with stiffness. The radiographs were suggestive chronic osteolytic cortical destruction diffuse sclerosis. We managed them a...

Infected total knee arthroplasty (TKA) due to Mycobacterium abscessus is very rare with only three such cases described in literature. Only one case was managed successfully, however, with a prolonged course of anti tubercular therapy. In this case report, we present an elderly lady with infected TKA after 2 years of the primary procedure. Although initially it grew different bacteriae, M. absc...

the musculoskeletal extrapulmonary tuberculosis is uncommon, the upper extremity tuberculosis is not common and the mycobacterial involvement of skin of hands and synovial sheath of tendons is rare. this prospective observational study was undertaken between august  2014 and december 2015 in a tertiary referral hospital. patients attending with suspected primary tuberculosis of soft tissue of t...

Introduction: Tubercular breast abscess is one of rare tuberculosis affecting women. Breast tuberculosis most commonly presents as a lump in the central or upper outer quadrant of the breast and discharge from nipple. Materials and Methods: This hospital-based prospective study was carried out at our tertiary care hospital from March 2013 to February 2015 on 197 female patients presenting with ...

The physiology of M. tuberculosis is highly aerobic and requires high levels of oxygen. Primarily a pathogen of the mammalian respiratory system, Mycobacterium Tuberculosis infects the lungs, causing tuberculosis. The Novel molecule which is linked by the unsaturated fatty acid compound and it is more abundant in nature sources. It possesses a broad spectrum of biological activities including a...

There are few reports of skeletal infections in patients with cirrhosis. We present two such cases, both with alcoholic liver disease, seen over a period of one year. The first, a 46-year-old man, presented as pyrexia of unknown origin, and was found to have pyogenic discitis; he responded to antibiotic and surgery. The second, a 42-year-old man, presented with chest wall abscess and was diagno...

Background: Ofloxacin is a fluoroquinolone antibiotic very useful in the treatment of several bacterial infections. The Thiazolidinone ring system represents privileged structure drug discovery. multi-drug-resistant tuberculosis bacteria infects many people worldwide and disease kills 1.8 million annually, so combination ofloxacin-thiazolidinone ...