Anti-angiogenesis is the therapeutic strategy designed to disrupt vascular supply and starve tumors of nutrients oxygen. This achieved mainly by blocking endothelial growth factor (VEGF) actions, as VEGF signaling pathway considered main angiogenesis promoter active in tumor microenvironment (TME) under hypoxic conditions. A total 16 anti-angiogenic agents, including anti-VEGF antibodies, recep...

Marine collagen peptides (MCPs) are natural products prepared by hydrolyzing marine protein through a variety of chemical methods or enzymes. MCPs have range structures and biological activities widely present in species. also small molecular weight, easily modified, absorbed the body. These properties attracted great interest from researchers studying antioxidant, anti-tumor, anti-aging activi...