Polypyrrole/silver (PPy/Ag)nanocomposite was synthesized by a chemical oxidative method. SEM and TEM analyses were performed for studying the morphology of the nanocomposite. It was shown that the obtained nanocomposite particles have a spherical structure with the high surface area to volume ratio that is the important factor in the biological application. The particle sizes of the P...

Inhibition of bacterial cell wall synthesis is an important mechanism of action of antibacterial agents. Bacterial cell walls are chemically and morphologically distinct from any structures found in animal cells. Inhibition of synthesis of these structures results, therefore, in selective toxicity. The antibacterial action of penicillins (1, 2), n-cycloserine (3, 4), bacitracin (5), and novobio...

This work examines the molecular mechanism of action of a class of bactericidal gold nanoparticles (NPs) which show potent antibacterial activities against multidrug-resistant Gram-negative bacteria by transcriptomic and proteomic approaches. Gold NPs exert their antibacterial activities mainly by two ways: one is to collapse membrane potential, inhibiting ATPase activities to decrease the ATP ...

The currently global and urgent need for alternative antimicrobial strategies to fight the continuous rise of microbial resistance led to a re-evaluation of the therapeutic use of ancient medicines such as honey. The antimicrobial (antibacterial, antifungal, and antiviral) properties of honey are dependent on physicochemical parameters, floral and entomological origin, harvesting process and st...

In the present investigation, two novel series of 2-[3-(4-chlorophenyl)propan-3-one]-5-(substituted phenyl)-1,3,4-oxadiazole and 2-[3-(4-ethylphenyl)propan-3-one]-5-(substituted phenyl)-1,3,4-oxadiazole were synthesized and tested for their antiinflammatory, analgesic, ulcerogenic and antibacterial actions. A fair number of compounds were found to have very good antiinflammatory activity in car...

Many attempts have been made in the past to find chemotherapeutic agents active against the tubercle bacillus, and some agents alleged to have had such action, notably gold compounds, have had a considerable vogue. The discovery of the antibacterial action of the sulphonamides stimulated a search for compounds of related constitution having an action against the tubercle bacillus, and this resu...

A layer of silver nanoplates, specifically synthesized with the desired localized surface plasmon resonance (LSPR) features, was grafted on amino-functionalized bulk glass surfaces to impart a double antibacterial action: (i) the well-known, long-term antibacterial effect based on the release of Ag⁺; (ii) an "on demand" action which can be switched on by the use of photo-thermal properties of s...

After it had been shown that the phenyl ether of ethylene glycol possessed antibacterial properties against Pseudomonas aerunosa (Berry, 1944) the antimicrobial and pharmacological activities of a number of related compounds were evaluated. Two of the compounds investigated in this connection have found clinical usefulness. These are mephenesin,3-o-toloxy-1, 2propanediol, widely used as a muscl...

The objective was to analyse the antibacterial ability of members of the intestinal microbiota of Oncorhynchus mykiss specimens on several bacterial target strains that contaminate food and cause disease in humans. Bacterial colonies from an intestinal portion of the 20 specimens of O. mykiss were obtained in different culture media. Several of the colonies showed antibacterial action on differ...

Many attempts have been made in the past to find chemotherapeutic agents active against the tubercle bacillus, and some agents alleged to have had such action, notably gold compounds, have had a considerable vogue. The discovery of the antibacterial action of the sulphonamides stimulated a search for compounds of related constitution having an action against the tubercle bacillus, and this resu...