WCK 771 demonstrated MIC(50) and MIC(90)s of 0.03 and 1 microg/ml, respectively, against 297 recent U.S. community-acquired and hospital strains of Staphylococcus aureus, irrespective of quinolone or glycopeptide resistance. Against quinolone-resistant strains, MIC(90)s of WCK 771 and moxifloxacin were 1 and 16 microg/ml, respectively.

Nanohydroxyapatite (n-HA)/zinc oxide (ZnO) complex was synthesized by a direct precipitation method, and the antibacterial capability and antibacterial mechanism of this complex were investigated in this article. Transmission electron microscope (TEM), Fourier transform infrared, X-ray photoelectronic spectroscopy (XPS), and X-ray diffraction (XRD) were used to analyze the materials. In additio...

objective(s): the present study was designed to investigate the antibacterial function and pharmacological effect of elephant garlic (allium ampeloprasum var. ampeloprasum) on u2os human osteosarcoma cells.   materials and methods: seven kinds of bacteria were reconstituted, inoculated and tested in this research to evaluate elephant garlic antibacterial activity. by the means of facs analysis,...

Vanillin, a plant-derived antimicrobial volatile substance, has potential microbial control applications in the food industry. However, effect of vanillin on food-borne pathogen Escherichia coli (E. coli) O157:H7 not been well studied. This study aims to explore antibacterial mechanism against E. O157:H7. The minimum inhibitory concentration (MIC) and were determined by microdilution. Scanning ...

INTRODUCTION ...... . CHEMISTRy ...... . 199 200 RELATIONSHIPS BETWEEN CHEMICAL STRUCTURE AND ANTIBACTERIAL ACTIVITY.. 202 MECHANISM OF ANTIBACTERIAL ACTION. . . . . . . . 205 Activity 0/1 whole cells. . . . . . . . . .. . . . . . . . . . . 205 Activity Oil DNA-depelldellf RNA polymerase. 205 MUTATION TO RIFAMPICIN RESISTANCE. . . . . . 206 EFFECTS ON PHAGES AND PLASMlDS. . . . . . 208 STUDIES ...

MM45289 (A82846A, eremomycin), a glycopeptide antibiotic of the vancomycin type, was confirmed to have improved antibacterial activity over vancomycin. However its affinity (Ka) for the target site peptide mimetic diacetyl-L-lysyl-D-alanyl-D-alanine (DALAA)was 23-fold lower. Concentrations of DALAArequired to reverse the antibacterial activity of MM45289 were in the order of 10 to 50-fold highe...

Very few chemically novel agents have been approved for antibacterial chemotherapies during the last 50 yr. Yet new antibacterial drugs are needed to reduce the impact on global health of an increasing number of drug-resistant infections, including highly drug-resistant forms of tuberculosis. This review discusses how genetic approaches can be used to study the mechanism of action of whole-cell...