A case of septic arthritis of the knee caused by Pseudomonas cepacia following an intraarticular corticosteroid injection in a patient with a history of osteoarthritis is presented. This is the second report of this agent causing infection in a diarthrodial joint, which proved difficult to eradicate despite in vitro antibiotic sensitivity.

Nine neonates with culture proved gonococcal ophthalmia neonatorum were treated with a single intramuscular injection of 100 mg/kg of cefotaxime without topical antibiotic therapy. Five of the nine strains were penicillinase-producing Neisseria gonorrhoeae. All nine cases were clinically and microbiologically cured, and no side effects were observed.

Authors report a case of acute paraplegia due to an epidural spinal abscess caused by a heroin injection that happened four months before. A complete neurological recovery is obtained by surgical decompression and antibiotic therapy despite the preoperative neurological status. The need for a surgical stabilization following extensive laminectomy is discussed.

The pharmacokinetics of the new triamilide antibiotic tulathromycin was investigated in two cattle studies. Following a single subcutaneous injection, the drug was rapidly absorbed and bioavailability was excellent. High and persistent levels of the drug in lung tissue were observed as well. These attributes are advantageous for an antimicrobial drug indicated for the treatment of bacterial and...

Antibiotic complex 4205, a basic polypeptide, was isolated from a nonsporulating bacillus. It was separated into two components, A and B, each composed of 2,4-diaminobutyric acid, isoleucine, leucine, phenylalanine, serine, and valine, but in different proportions, namely, 4:1:2:1:1:1 and 5:1:3:1:2:2, respectively. There was also an ether-soluble moiety in each that had the characteristics of a...

A 20-gauge cannula placed via an interscalene approach in the left brachial plexus sheath of a healthy 18-yr-old male was used inadvertently for injection of 20 ml of antibiotic solution, despite clear labelling of the cannula and painful protest from the patient. The patient suffered no neurological sequelae. The treatment, possible causes and steps to avoid similar incidents are described.

The antitumor activity of a novel ansamycin antibiotic, trienomycin A, against various murine tumors was studied with two treatment schedules. The intraperitoneal injection of the antibiotic showed remarkable antitumor activity on sarcoma 180 and P388 leukemia at doses of 160 or 320 mg/kg, showing 151% and 100% increase in life span, respectively. Trienomycin A inhibited the growth of Ehrlich a...

BACKGROUND To report a case of Streptococcus mitis/oralis endophthalmitis management which had developed after complicated iris-fixated phakic intraocular (pIOL) lens implantation. CASE PRESENTATION A 23-year-old-woman received pIOL implantation followed secondary intraocular intervention to lower intraocular pressure. The patient presented with severe pain and decreased visual acuity and was...

Nicolau syndrome (NS) is a rare complication of intramuscular, intraarticular or subcutaneous injection of particular drugs leading to ischemic necrosis of the surrounding skin, soft tissue and muscular tissue. Benzathine penicilin one of the most widely used antibiotic for upper respiratory tract infections and has been rarely reported to cause NS. Here we describe a 4 year old boy with diagno...