Red Cells, Fresh Frozen Plasma (FFP) and Platelets (RDP/SDP) prepared from donors with group O may have high titers of anti-A, anti-B and/or anti-A,B antibodies. When such components given to non-group patients, this titre can result in haemolytic transfusion reactions (HTRs). Such are generally termed ‘high-titer donors. Significant amounts ABO antigen being present on the platelet surface ant...

BACKGROUND Establishing antibody correlates of protection against malaria in human field studies and clinical trials requires, amongst others, an accurate estimation of antibody levels. For polymorphic antigens such as apical membrane antigen 1 (AMA1), this may be confounded by the occurrence of a large number of allelic variants in nature. METHODS To test this hypothesis, plasma antibody lev...

Ten antisera were produced in rabbits by two or three intravenous injections of inactivated whole influenza type A virions. All contained haemagglutination-inhibition (HI) antibody directed predominantly to an epitope in antigenic site B and, in addition, various amounts of antibodies to an epitope in site A and in site D. The ability of untreated antisera to select neutralization escape mutant...

Two cases of Waldenström's macroglobulinaemia have been seen at University College Hospital, Ibadan in the last four years, Case 1 was a 30-year-old soldier who presented with splenomegaly and anaemia, was treated with chlorambucil, and had a complete remission sustained for over two years. Case 2 was a 58-year-old retired civil servant who presented with very severe anaemia and also splenomega...

This study was conducted to evaluate the effects of dietary inclusion of thyme essential oil (TEO) on growth performance and immune responses of broiler chicks subjected to heat stress (HS). Broilers were divided into five groups; group 1) chicks fed with basal diet and reared under thermoneutral condition; group 2) chicks fed with basal diet and subjected to HS condition; and groups 3, 4 and 5...

Pneumocystis carinii pneumonia (PCP) is a frequent cause of pneumonia among human immunodeficiency virus (HIV)-infected patients. Little is known, however, about the role played by humoral immunity to control the infection. This study was undertaken to elucidate the role played by local antibodies. Bronchoalveolar lavage (BAL) fluids from 18 acquired immune deficiency syndrome (AIDS) patients w...

OBJECTIVE To investigate the immunogenicity of Haemophilus influenzae type b (Hib) conjugate vaccines in children with sickle cell disease. DESIGN Open study. SETTING Haemoglobinopathy clinic. SUBJECTS Children with homozygous haemoglobin SS disease (HbSS), sickle haemoglobin C disease (HbSC), and sickle-beta thalassaemia disease (HbS-beta Thal). INTERVENTIONS Children over the age of 2...

roglobulin, antimicrosome, or antiskeletal muscle autoantibodies whereas the generalised type showed a high titre and incidence of autoantibodies including AChR antibody.5 Seronegative patients or those with low AChR antibody may form a low responder subgroup of myasthenia gravis distinct from the high responders, who show a high titre of AChR antibody. Twelve patients (37 5%) were of the ocula...

We investigated the effectiveness of the mass measles vaccination campaign in Urmia, Islamic Republic of Iran, by examining the measles IgG seroprevalence and antibody response from paired data before and after the campaign. The overall seropositive rate of 624 subjects aged 5-25 years increased 1 year after the mass vaccination (from 53.0% to 72.3%). A rise in antibody titre occurred in all ag...