Benzothiazole, the bicyclic ring system consists of thiazole ring fused with benzene ring. The literature study of benzothiazoles reveals that the presence of this bicyclic ring system in various amine or terrestrial natural compounds possess different biological properties. Thus benzothiazole moiety is continuously drawing interest for development of newer drug moiety due to its wide range of ...

Abstract Background Nanoparticulate drug delivery systems have attracted significant attention in the field of cancer nanotechnology. This study determines the effect of folate-based Fe2O3 nanoparticles. This study aimed to decorate nanoparticles with folate (FA), a molecular ligand for ‘active’ targeting of cancerous cells and the application of modified-nanoparticles in cancer treatment. ...

The small molecule anticancer agent NSC-743380 modulates functions of multiple cancer-related pathways and is highly active in a subset of cancer cell lines in the NCI-60 cell line panel. It also has promising in vivo anticancer activity. However, the mechanisms underlying NSC-743380's selective anticancer activity remain uncharacterized. To determine biomarkers that may be used to identify res...

In his comprehensive review, Dr. Rajkumar provides a summary of the current status of thalidomide (Thalomid) therapy in cancer. As discussed in the article, it was the teratogenic effects, particularly phocomelia, that prompted researchers to examine thalidomide’s antitumor activity in the 1960s. Although, the results of early phase I trials of thalidomide as an anticancer agent were disappoint...

This article describes a method developed for predicting anticancer/non-anticancer drugs using artificial neural network (ANN). The ANN used in this study is a feed-forward neural network with a standard back-propagation training algorithm. Using 30 'inductive' QSAR descriptors alone, we have been able to achieve 84.28% accuracy for correct separation of compounds with- and without anticancer a...

OBJECTIVE Australia has a publicly funded universal healthcare system which heavily subsidises the cost of most registered anticancer drugs. The use of anticancer drugs that are unfunded, that is, not subsidised by the government, entails substantial out-of-pocket costs for patients. We sought to determine how frequently Australian medical oncologists discuss and prescribe unfunded anticancer d...

Presence of vitamin D receptors in noncalcemic tissues and subsequent identification of its involvement in growth factor(s)-mediated cellular function suggested its probable beneficial role in genesis, progression and survival of cancerous growths. Data collected from both in vitro and in vivo studies are highly optimistic regarding its potential in prevention and regression of colorectal, pros...

OBJECTIVE The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes. MATERIALS AND METHODS Google scholar, PubMed and Scopus were searched for literatures whi...

Itraconazole, a common anti-fungal agent, has demonstrated potential anticancer activity, including reversing chemoresistance mediated by P-glycoprotein, modulating the signal transduction pathways of Hedgehog, mechanistic target of rapamycin and Wnt/β-catenin in cancer cells, inhibiting angiogenesis and lymphangiogenesis, and possibly interfering with cancer-stromal cell interactions. Clinical...

Rupseh Dudhe *, Pramod Kumar Sharma, Prabhakar Verma, Anshu Chaudhary a Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, NH-58, Baghpat Bypass Crossing, Meerut (U. P.), India250005. Vishveshwarya Institute of Medical Science Dadri, Gautambudh Nagar (U.P.) India-203207. Uttarakhand Technical University, Dehradun (Uttarakhand), India248007. NIMS University, S...