BACKGROUND/AIMS Reduced clinical effect on cognitive decline in dementia by acetylcholinesterase inhibitors (AChEIs) may be due to concurrent use of drugs with anticholinergic properties. The aim was to analyze the incidence of AChEI use and comedication with drugs with anticholinergic properties and other potential unfavorable effects. METHODS A prospective study applying drug use data from ...

Poorer neuropsychological function is associated with increased medical burden (MB) and the use of more anticholinergic medications. However, the interaction between MB and anticholinergic cognitive burden (AB) on neuropsychological performance is unknown. In a sample of 290 elderly primary care patients, those with a greater level of AB demonstrated poorer Total Index performance on the Repeat...

Urinary incontinence is a prevalent condition affecting a disproportionate number of older women in the United States. Anticholinergic medications are the preferred treatment; however, a single anticholinergic agent has not emerged as the best treatment option. OnabotulimumtoxinA appears effective in the treatment of urgency urinary incontinence; however, it has led to incomplete voiding and th...

The effect of anticholinergic agents-atropine, propantheline, oxyphencyclimine, and propionyl atropine methyl nitrate-on silva flow and on hypoglycaemic stimulated gastric secretion has been studied. The acid secretion of the nervous phase of gastric secretion was inhibited by anticholinergic drugs. They influenced gastric secretion to a greater extent than saliva flow. Both propantheline and o...

Background: There are few studies on the anticholinergic side effects of long-acting antipsychotics. They tend to be used with stigmatized, severely ill and non-concordant patients rather than first episode psychosis. Aim: To investigate prevalence/incidence rate of anticholinergic side effects of long-acting antipsychotics. Methods: We included all participants with schizophrenia, schizoaffect...

OBJECTIVE To analyse anticholinergic agent consumption in HIV patients 50  years or older; to determine anticholinergic risk using the ACB and ARS scales;  and to determine if these patients use any type of benzodiazepine. METHOD A descriptive observational study of 256 HIV patients 50 years or  older. RESULTS 73.1% were men. Mean age was 56 ± 5.9 years. 55.9% of the  patients were coinfect...

black henbane (bh) or hyoscyamus niger, has been used as a medicine since last centuries and has been described in all traditional medicines. it applies as a herbal medicine, but may induce intoxication accidentally or intentionally. all part of bh including leaves, seeds and roots contain some alkaloids such as hyoscyamine, atropine, tropane and scopolamine. bh has pharmacological effects like...

Rabbit syndrome is described as a late onset extrapyramidal side effect of antipsychotic therapy. In the present case rabbit syndrome is described in a young adult as an acute complication of treatment with haloperidol which showed a favourable response to the anticholinergic treatment. Key Words: Rabit Syndrome, antipsychotics,anticholinergic agent.

AIM This study evaluated a presumed gradual decline in cognitive function in nursing home residents when the anticholinergic drug scale (ADS) score increased above 3. METHOD The study population was recruited from 21 nursing homes in Norway. Criteria for inclusion were ADS score ≥ 3 and no severe dementia, defined as Clinical Dementia Rating (CDR) score < 3. Primary cognitive end points were ...