Abstract SZJ-1207 is an antidepressant natural product with a steroidal structure extracted from Stephanotis mucronata . It novel candidate molecule and all its pharmacokinetic properties have not been reported. In this study in mice following oral administration, accurate sensitive UPLC-MS/MS method was established evaluated to measure concentrations mouse plasma brain samples. The results pro...

Objective(s) This study planned to assess antidepressant like activity of aqueous extract from leaves of Citrus maxima Merr. (Rutaceae). Materials and Methods Boiling was used for aqueous extraction. Acute toxicity study was performed in mice. Antidepressant activity was studied using locomotor activity test, modified forced swimming test (FST) and tail suspension test (TST). Three doses 100...

Introduction: Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. Am...

introduction: regarding the high rate of depression in our society, using anti-depressive drugs especially tricycle antidepressants (tcas) is increasing and poisoning by these agents has become more common than other drugs. due to its incident and dire complications we decided to study the treatment quality in poisoned patients with tcass admitted in emergency ward of arak,s vali-e-asr hospital...

With the aim of obtaining information about drug-drug interaction (DDI) between acetaminophen and some of antidepressant drugs (fluoxetine, sertraline and nortriptyline), in the present work we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of these drugs by means of cyclic voltammetry and Controlled-potential coulometry. The reaction between N-acetyl-p-ben...

objective: rosa damascena mill l (r. damascena) is a medicinal plant mostly known in the world for its perfume. it also has beneficial effects on stress, tension and depression. in this experiment antidepressant effect of ethanolic extract of r. damascena by forced swimming test (fst) was evaluated. material and methods: animals received ethanolic extract (15, 60 and 90 mg/kg, i.p), imipramine ...

BACKGROUND Concerning the risk of antidepressant induced liver injury, it is not clear whether psychiatrists perform a liver function test (LFT) and whether an increase in aminotransferase levels should contraindicate antidepressant treatment. AIM To evaluate LFT availability, the prevalence of LFT abnormalities and the probable cause of an altered LFT in patients with a major depressive epis...

CONTEXT In June 2003, the Food and Drug Administration (FDA) recommended that paroxetine hydrochloride not be used to treat young people because of potential increased risk of suicidal behavior, and in October 2004, the FDA issued a black box warning concerning all antidepressants for youth. OBJECTIVE To characterize associations between these warnings and antidepressant use. DESIGN Interru...

BACKGROUND Different classes of antidepressant drugs are used as a treatment for depression by activating the catecholinergic system. In addition, depression has been associated with decrease of growth factors, which causes insufficient axonal sprouting and reduced neuronal damage repair. In this study, antidepressant treatments are analyzed in a cell culture system, to study the modulation of ...